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1.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Sep 5;31(17):1327-1329. doi: 10.13201/j.issn.1001-1781.2017.17.007.

[Interpretation of allergic rhinitis and its impact on asthma (ARIA)].

[Article in Chinese]

Abstract

Allergic rhinitis and its impact on asthma (ARIA) has been the most preferred reference for national guidelines. The ARIA 2010 revision is the first evidence-based clinical guideline in the field of allergies, which has great influence in the world. The ARIA 2016 revision continues the basic framework of the 2010 revision, which focuses on six controversial clinical issues in the treatment of allergic rhinitis.It aimed to provide clear informationand systematic treatment for patients, clinicians and health policy makers. The interpretation of the ARIA 2016 revision will help domestic otolaryngologist, respiratory doctors, and allergy practitioners understand the latest guidelines for AR drug treatment in the world.

KEYWORDS:

asthma; drug treatment; rhinitis, allergic

[Indexed for MEDLINE]
2.
Wiad Lek. 2018;71(3 pt 2):699-704.

Prevalence of risk factors of allergic diseases among children aged 8-9 years in poltava region (the results of the first stage of the research).

Author information

1
Higher State Educational Establishment Of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.

Abstract

OBJECTIVE:

Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region.

PATIENTS AND METHODS:

Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification.

RESULTS:

Results: 1068 children who are 8-9 years old were interviewed based on questionnaires: 56,2% males and 43,8% females. Children were divided into residents (49,2%), and villagers (50,8%). In order to identify allergic diseases the division in family was the next: the presence of bronchial asthma was present in 38 people (3,6%), allergic rhinitis or allergic conjunctivitis - 128 people (12,0%), atopic dermatitis - 54 people (5,1%), food allergy - 129 people (12,1%), medicinal allergy - 25 people (11,7%). Analyzing the influence of trigger factors, it should be noted that in the risk group there are children who received cow's milk as substitutes for breast milk (38.1%), children who had a history of helminthal invasion (19.6%), children where parents smoke (45.9%), one third of parents (31.9%) complained of frequent respiratory viral infections in their children.

CONCLUSION:

Conclusions: Presented epidemiological investigation allowed studying the prevalence of diagnosed allergic diseases in children of Poltava region and determining children's category who require additional diagnostics of chronic allergic diseases.

KEYWORDS:

allergic diseases; asthma; risk factors; children

PMID:
29783251
[Indexed for MEDLINE]
3.
Int Arch Allergy Immunol. 2018;176(2):143-149. doi: 10.1159/000488329. Epub 2018 May 16.

Associations of Current Wheeze and Body Mass Index with Perennial and Seasonal Allergic Rhinitis in Young Adults.

Author information

1
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
2
Hokkaido University Health Care Center, Sapporo, Japan.

Abstract

BACKGROUND:

The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to evaluate the coexistence of current wheeze and two types of AR and the impact of body mass index (BMI) on these two conditions in Japanese young adults.

METHODS:

First-year students from Hokkaido University were enrolled into this study from 2011 to 2016. A questionnaire survey including the prevalence of current wheeze, PAR, and SAR every year for 11,917 nonsmoking young adults was conducted. The difference in the impact of current wheeze and BMI on these two types of AR was separately evaluated.

RESULTS:

Although both PAR and SAR were significantly associated with current wheeze, the impact of these two AR types on current wheeze was different (OR for PAR = 2.46 vs. OR for SAR = 1.29). When we classified all of the subjects into 4 groups with or/and without the two types of AR, the prevalence of current wheeze was significantly higher in subjects with PAR than in those without PAR (p < 0.001). However, the prevalence of current wheeze did not differ between subjects with or without SAR. Multinomial regression analyses showed that the association of wheeze with PAR and/or SAR was stronger compared to that of wheeze with SAR without PAR. The prevalence of PAR was not associated with BMI. Contrarily, a low BMI was significantly associated with a high SAR prevalence (p < 0.05).

CONCLUSION:

Comparisons between PAR and SAR showed that the conditions are differentially associated with current wheeze and BMI.

KEYWORDS:

Allergic rhinitis; Body mass index; Current wheeze; Perennial allergic rhinitis; Seasonal allergic rhinitis

PMID:
29768270
DOI:
10.1159/000488329
[Indexed for MEDLINE]
Icon for S. Karger AG, Basel, Switzerland
4.
Niger J Clin Pract. 2018 May;21(5):632-638. doi: 10.4103/njcp.njcp_343_17.

The prevalence of allergic diseases among children with asthma: What is the impact on asthma control in South East Nigeria?

Author information

1
Department of Pediatrics, College of Medicine, University of Nigeria Enugu Campus, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria; Division of Pediatric Pulmonology, Red Cross Children Hospital, University of Cape Town, Cape Town, South Africa.
2
Department of Pediatrics, College of Medicine, University of Nigeria Enugu Campus, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

Abstract

Background:

Allergic diseases are known to occur in children with asthma and its coexistence with asthma may impact on asthma control in affected children living in a low-income country. The study is to determine the allergic profile of children with asthma and the association with asthma control and attendant social risk factors.

Materials and Methods:

This was a cross-sectional study of consecutively enrolled children with physician diagnosed asthma, attending clinics in a tertiary center in Nigeria. The presence of asthma, allergy types, and asthma control levels were determined using the Gobal initiative on asthma (GINA), international study of asthma and allergy in childhood and asthma control test questionnaires, respectively.

Results:

There were 207 children with asthma enrolled from the Pediatric Asthma Clinic at University of Nigeria Teaching Hospital, Enugu. The median age was 10 years and interquartile range of 7-11 years. There were 127 (61.4%) from middle and high socioeconomic class and 86.5% who lived in the urban areas. Of the study participants, 41.5% had one or more allergy symptoms; rhinitis (33.3%), conjunctivitis (29.0%), and dermatitis (7.2%). Allergy symptoms persisted from infancy in 55.9%. Children from large families had a lower prevalence of allergies. Having any allergy symptom and belonging to a small-sized family were both associated with asthma exacerbations. Most children studied, (69.1%) had their asthma under control. Allergy persistence from infancy and type of allergy were not significantly associated with the level of asthma control.

Conclusion:

Allergic diseases are common in children with asthma in our environment, but did not significantly impact on asthma control. Socioeconomic factors such as urbanization and family size had effects on the achievement of asthma control but not on allergy status.

KEYWORDS:

Allergy; asthma; children; control; severity

PMID:
29735865
DOI:
10.4103/njcp.njcp_343_17
[Indexed for MEDLINE]
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5.
Eur Arch Otorhinolaryngol. 2018 Jun;275(6):1483-1490. doi: 10.1007/s00405-018-4979-3. Epub 2018 Apr 19.

Influence of MP 29-02 on ciliary beat frequency in human epithelial cells in vitro.

Author information

1
Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. daniel.haeussler@umm.de.
2
Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany. daniel.haeussler@umm.de.
3
Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. ulrich.sommer@umm.de.
4
Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany. ulrich.sommer@umm.de.
5
Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
6
Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
7
Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Marburg, Marburg, Germany.
8
Philipps-Universität Marburg, Marburg, Germany.

Abstract

PURPOSE:

MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far.

METHODS:

MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope. CBF was measured after the application of MP 29-02. For a comparison, fluticasone propionate was used. CBF measurements were then performed for 15 min at 22 °C. Ringer's solution was applied as a negative control.

RESULTS:

MP 29-02 significantly reduced CBF at all the tested concentrations compared with that of the control group within the observation time. At a 2.5% concentration, MP 29-02 significantly reduced CBF from 6.81 Hz (SD ± 1.35 Hz) at baseline to 4.88 Hz (SD ± 1.52 Hz, p < 0.001) after 15 min. In contrast, for fluticasone propionate, a significant reduction was observed only with the 20% concentration after 5, 10, and 15 min.

CONCLUSIONS:

MP 29-09 significantly reduced CB, with an almost linear relationship between the MP 29-09 concentration and reduction in CBF. For fluticasone propionate, a significant reduction of CBF was observed only at the highest analyzed concentration. The findings have implications for the long-term use of the MP 29-02. Yet, further clinical studies are needed to confirm these results in vivo, especially in patients with seasonal or perennial allergic rhinits.

KEYWORDS:

CBF; Ciliary beat frequency; Dymista; Flutide; MP 29-02

PMID:
29675754
DOI:
10.1007/s00405-018-4979-3
[Indexed for MEDLINE]
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6.
J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1):83-88.

House dust mite sublingual-swallow immunotherapy in perennial rhinitis: a double-blind, placebo-controlled Iranian study.

Author information

1
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran.

Abstract

Sensitivity to house dust mite allergens in the development of allergic rhinitis has a key role. In this study, the clinical and immunological effects of high dose Dermatophagoides farinae sublingual immunotherapy (SLIT) versus placebo were compared. Forty poly-sensitized patients, ages 6-33 years, with allergic rhinitis and positive allergic reaction to the mites were enrolled in the study. Twenty-one patients were placed in the SLIT group and 19 in the placebo group. Expression levels of IL-10, TGF-β, FOXP3 and IL-17 were measured by using real-time PCR before and after the administration of sublingual immunotherapy. Clinical efficacy was estimated by the reduction rate of symptom/medication scores in the SLIT group compared with placebo treatment. After 6 months of SLIT, TGF-β expression levels were increased compared to pre-treatment (P less than 0.05). SLIT with D. Farinae extract is an effective treatment for poly-sensitized patients with allergic rhinitis. TGF-β mediated T-cell suppression may be an important mechanism in the first 6 months of SLIT.

PMID:
29504369
[Indexed for MEDLINE]
7.
Vestn Otorinolaringol. 2017;82(6):52-59. doi: 10.17116/otorino201782652-59.

[Possibilities of azelastine in the treatment of chronic rhinitis].

[Article in Russian; Abstract available in Russian from the publisher]

Author information

1
State Research Center 'Institute of Immunology', the Federal Medical-Biological Agency of Russia, Moscow, Russia, 115478.

Abstract

There is considered modern classification of rhinitis and the accents in diagnostic and therapeutic approaches to patients with this disease are indicated, as well as the possibilities of using topical intranasal antihistamines in the treatment of allergic, vasomotor and medicamentous rhinitis.

KEYWORDS:

allergic rhinitis; azelastine; intranasal glucocorticoids; topical intranasal antihistamines; vasomotor rhinitis

PMID:
29260783
DOI:
10.17116/otorino201782652-59
[Indexed for MEDLINE]
8.
BMJ Open. 2017 Sep 27;7(9):e016556. doi: 10.1136/bmjopen-2017-016556.

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial.

Author information

1
Department of Ophthalmology, Otorhinolaryngology, and Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
2
Department of Clinical Korean Medicine, Graduate school, Kyung Hee University, Seoul, Republic of Korea.
3
Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Abstract

INTRODUCTION:

So-Cheong-Ryong-Tang (SCRT) is a herbal medicine widely used in traditional medicine for treating allergic rhinitis (AR). In animal studies, SCRT has suppressed the progression of AR. The main purpose of this study is to assess the efficacy and safety of the SCRT for the treatment of perennial allergic rhinitis (PAR) and discover the underlying mechanisms resulting in anti-inflammatory effects in humans.

METHODS AND ANALYSIS:

We will conduct a double-blind, randomised, placebo-controlled, parallel-group, multicentre trial of Korean adults with PAR. For the study, 156 subjects with PAR will be recruited. The trial will consist of a 4-week oral administration of SCRT or placebo with two visits at 2-week intervals and an 8-week follow-up period with two visits at 4-week intervals. The primary outcome is a change in the total nasal symptoms score. The secondary outcomes include changes in the Rhinoconjunctivitis Quality of Life Questionnaire score, total serum IgE and cytokines levels.

ETHICS AND DISSEMINATION:

This study was approved by the Institutional Review Board at each research centre (name of each centres and approval numbers): Kyung Hee University Hospital at Gangdong (KHNMC-OH-IRB 2015-04-009), Kyung Hee University Medical Centre (KOMCIRB-160321-HRBR-011), Pusan National University Hospital (2016-004), Dongguk University Medical Centre (2016-03) and Semyung University hospital (2016-01). This result will be published in a peer-reviewed journal.

TRIAL REGISTRATION NUMBER:

NCT03009136; Pre-results.

KEYWORDS:

allergy; complementary medicine; otolaryngology

PMID:
28963290
PMCID:
PMC5623494
DOI:
10.1136/bmjopen-2017-016556
[Indexed for MEDLINE]
Free PMC Article
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9.
Genet Mol Res. 2017 Jul 6;16(3). doi: 10.4238/gmr16039641.

Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand.

Author information

1
Department of Parasitology, Faculty of Medicine, Siriraj Hospital, , , Thailand anchalee.tun@mahidol.ac.th.
2
Graduate Program in Microbiology, Department of Microbiology, Faculty of Medicine, Siriraj Hospital, , , Thailand.
3
Office for Research and Development, Faculty of Medicine, Siriraj Hospital, , , Thailand.
4
Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, , , Thailand.
5
Department of Otolaryngology, Faculty of Medicine, Siriraj Hospital, , , Thailand.
6
Department of Microbiology and Immunology, Faculty of Tropical Medicine, , , Thailand.
7
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, , , Thailand.
8
Department of Parasitology, Faculty of Medicine, Siriraj Hospital, , , Thailand.

Abstract

Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled study aimed to identify the possible relationship of the genetic variations in the IL-18 gene with AR in mite-sensitive Thai patients. Study subjects consisted of 150 AR patients and 50 normal participants. Genomic DNA of 30 randomized AR patients and 30 randomized controls were screened by sequencing for the selection of candidate single nucleotide polymorphisms (SNPs), and further analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for all subjects. The following five SNPs were detected in the IL-18 gene: -656 G/T, -607 C/A, and -137 G/C in promoter 1 and -920 C/T and -373 C/G in promoter 2. The results showed that -656 G/T and -607 C/A SNPs were significantly correlated with IgE levels specific to Dermatophagoides pteronyssinus (Der p) allergen (P = 0.045 and P = 0.045, respectively), and significant differences were observed in the genotype distribution of AR patients when compared with controls [P = 0.044 and P = 0.044, respectively; odds ratios (ORs): 1.941 (95%CI, 1.014-3.715) and 1.941 (95%CI, 1.014-3.715), respectively]. Our findings indicate that the IL-18 alleles, -656T (rs1946519) and -607A (rs1946518), might be associated with the higher production of Der p allergen-specific IgE in mite-sensitive AR patients.

PMID:
28692122
DOI:
10.4238/gmr16039641
[Indexed for MEDLINE]
12.
Eur Arch Otorhinolaryngol. 2017 Aug;274(8):3097-3101. doi: 10.1007/s00405-017-4604-x. Epub 2017 May 13.

Contralateral sinus involvement of surgically treated unilateral allergic fungal rhinosinusitis.

Author information

1
Department of Otolaryngology Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Qahtani24@hotmail.com.
2
Department of Otolaryngology Head and Neck Surgery, Dammam Medical Complex, Dammam, Saudi Arabia.
3
Department of Otolaryngology Head and Neck Surgery, King Khalid University, Aseer Central Hospital, Abha, Saudi Arabia.
4
Department of Otolaryngology Head and Neck Surgery, King Salman Hospital, Riyadh, Saudi Arabia.
5
Department of Otolaryngology Head and Neck Surgery, Khamis Mushait General Hospital, Khamis Mushite, Saudi Arabia.
6
Department of Otolaryngology Head and Neck Surgery, King Fahad Medical City, Riyadh, Saudi Arabia.
7
Department of Otolaryngology Head and Neck Surgery, King Khalid Hospital, Hail, Saudi Arabia.
8
Department of Otolaryngology Head and Neck Surgery, King Saud University Medical City, King Abdulaziz Hospital, Riyadh, Saudi Arabia.
9
Department of Otolaryngology Head and Neck Surgery, Umm Al-Qura University, Makkah, Saudi Arabia.
10
Department of Otolaryngology Head and Neck Surgery, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
11
Department of Otolaryngology Head and Neck Surgery, Prince Mohammed bin Naser Hospital, Jazan, Saudi Arabia.

Abstract

Recurrence of allergic fungal rhinosinusitis (AFRS) is well recognized. However, there is scarcity in the literature describing involvement of the non-diseased sinuses. We aimed to evaluate the recurrence forms of unilateral AFRS as well as to study the possible predictor factors of developing the disease in the contralateral side. Patients with exclusive unilateral AFRS from (2010 to 2015) were enrolled in multi-institutional case-control study. All patients were evaluated after endoscopic sinus surgery for recurrence. Patient's records were reviewed for demographics, medical treatment, and clinical, radiological, and surgical data. A total of 68 patients were identified. Delayed contralateral involvement after the initial surgery was found in 30.8% with mean duration of recurrence 16.9 months. A significant association was found with the presence of pre-operative contralateral symptoms and signs of inflammation (OR 3.49, 95% CI 1.19-10.22, p value 0.02). Post-operative use of budesonide irrigation was associated with less contralateral involvement (OR 0.11, 95% CI 0.01-0.87, p value 0.01). Association of other variables like: comorbidities, perioperative use of systemic steroid, radiological signs, extent of surgery, additional surgery to the contralateral side, and post-operative use of systemic steroids did not show statistical significance. Involvement of the contralateral sinuses in 30% of unilateral AFRS cases is considered significant. The non-diseased sinuses should be involved in the routine endoscopic examination and post-operative treatment. Further studies are necessary to investigate the possibility of prophylactic surgical intervention of the non-diseased sinuses.

KEYWORDS:

Allergic fungal rhinosinusitis; Budesonide; Contralateral; FESS; Recurrence

PMID:
28501959
DOI:
10.1007/s00405-017-4604-x
[Indexed for MEDLINE]
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13.
Pediatr Allergy Immunol. 2017 Aug;28(5):438-445. doi: 10.1111/pai.12724. Epub 2017 Jun 19.

Nasal obstructive disorders impair health-related quality of life in adolescents with persistent allergic rhinitis: A real-life study.

Author information

1
Unitat de Rinologia Pediàtrica, Otorhinolaringology Department, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.
2
Unitat de Rinologia i Clínica de l'Olfacte, Otorhinolaringology Department, Hospital Clínic, Universitat de Barcelona, CIBERES, Barcelona, Catalonia, Spain.
3
Immunoal∙lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
4
Unidad de Rinología, Servicio de Otorrinolaringología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
5
Sección de Inmunoalergología, Servicio de Pediatría. Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.

Abstract

BACKGROUND:

We previously reported a higher prevalence of nasal obstructive disorders (NOD) in pediatric patients with persistent allergic rhinitis (PER) not responding to medical treatment. The aim of this study was to determine the impact of NOD on quality of life (QoL) in this population.

METHODS:

Real-life prospective study including 142 patients (41 children, 6-11 years old and 101 adolescents, 12-17 years old) with moderate and severe PER. After 2 months of medical treatment (intranasal steroids and antihistamines), patients were asked whether their symptoms had improved (yes/no) and classified accordingly in R, responders and NR, non-responders. Nasal symptoms (visual analog scale, VAS), NOD (nasal endoscopy), and QoL (PRQLQ, AdolQRLQ) were also assessed.

RESULTS:

Sixty-nine adolescents and 24 children were included in the NR group. NR presented worse QoL overall scores in adolescents (3.16±1.1 vs 1.63±0.99; P=.00001) and children (2.19±0.82 vs 1.51±0.77, P=.02). Medical treatment failure was associated with worse outcomes in QoL (adolescents OR: 1.6, P<.0001; children OR: 1.04, P=.036). Female adolescents presented worse QoL scores than males (3.19 vs 2.36, P=.001). The presence of obstructive septal deviation (OR: 1.02, P=.005), obstructive turbinate hyperplasia (OR: 1.03, P=.0006), and coexistence of both (OR=2.06, P=.001) was associated with worse QoL in adolescents. A strong and highly significant correlation was found between nasal symptoms VAS and QoL.

CONCLUSION:

The presence of NOD, particularly in adolescents, is associated with poor QoL outcomes. Assessment of NOD in pediatric PER should be considered an essential approach to determine the response to treatment and its impact on patient's QoL.

KEYWORDS:

adolescent; children; nasal obstruction; pediatric; persistent allergic rhinitis; quality of life; septal deviation; turbinate hyperplasia

PMID:
28423474
DOI:
10.1111/pai.12724
[Indexed for MEDLINE]
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14.
J Fam Pract. 2017 Apr;66(4 Suppl):S58-S63.

Hot Topics in Primary Care: Sublingual Immunotherapy: A Guide for Primary Care.

Author information

1
Clinical Professor of Pediatrics, Division of Allergy and Immunology, University of California, San Diego, CA, USA.

Abstract

Allergen immunotherapy (AIT), the only potential disease-modifying treatment for allergic disease, has been used for more than a century. Hankin et al showed significant reduction in pharmacy, outpatient, and inpatient resources in the 6 months following vs the 6 months preceding AIT in Medicaid-enrolled children with allergic rhinitis (AR). A 2013 analysis showed sustained cost reduction over 18 months in patients with AR treated with AIT compared with matched control subjects not treated with AIT.

PMID:
28375410
[Indexed for MEDLINE]
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15.
Laryngorhinootologie. 2017 Feb;96(2):89-97. doi: 10.1055/s-0043-101391. Epub 2017 Mar 14.

[Seasonal and Perennial Allergic Rhinoconjunctivitis].

[Article in German]

Author information

1
Augenklinik, Universitätsklinikum Düsseldorf, Düsseldorf.
2
Hautklinik, Universitätsklinikum Düsseldorf, Düsseldorf.
3
HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf.

Abstract

Seasonsal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) as well as intermittent and persistent allergic rhinitis are widespread diseases. Because a combined occurrence of ocular and nasal symptoms is very common the summarising term allergic rhinoconjunctivitis is frequently used. SAC and PAC representing the two acute forms of allergic conjunctivitis account for more than 90% of all cases of allergic conjunctivitis. Compared to the chronic forms of allergic conjunctivitis their course of disease is milder. Nevertheless because of their high prevalence and the proven influence on patients' quality of life they possess clinical and socioeconomic relevance. Allergic rhinoconjunctivitis is caused by a type 1 IgE-mediated hypersensitivitity reaction that is provoked by aeroallergens in the majority of cases. The pathognomonic sign is itching. Besides, typical ocular findings are chemosis, conjunctival injection,watery secretion and lid swelling. Otorhinolaryngologists' findings include rhinorrhea, postnasal drip and sneezing. Problems in breathing through the nose resulting from nasal obstruction can cause impaired nighttime sleep and daytime somnolence. In addition to a reduction of allergen exposure by modification of environment and life style factors, in mild forms of SAC and PAC artificial tears are recommended. Topical antihistamines can generate rapid relief from acute symptoms and itching. Topical mast cell stabilisers however provide long-term effects. Dual action drugs that combine antihistamines and mast cell stabilisers show increased patient compliance due to reduced application frequency. Use of topical steroids should be cautious and only temporary. For prolonged treatment periods unpreserved anti-allergic eye-drops should be preferred. Combined topical antihistamines and new-generation topical nasal steroids often used by otorhinolaryngologists demonstrate a good safety profile without systemic side effects. In summary, allergic rhinoconjunctivitis represents a common disease pattern that can be treated effectively. Once it is diagnosed correctly targeted treatment results in improved patients' quality of life quickly.

PMID:
28291999
DOI:
10.1055/s-0043-101391
[Indexed for MEDLINE]
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16.
Pediatr Allergy Immunol. 2017 Jun;28(4):393-397. doi: 10.1111/pai.12707. Epub 2017 Mar 28.

Nasal budesonide efficacy for nasal nitric oxide and nasal obstruction in rhinitis.

Author information

1
Department of Science for Health Promotion for Mother and Child Care, University of Palermo, Palermo, Italy.
2
Institute of Biomedicine and Molecular Immunology, National Research Council of Italy, Palermo, Italy.
3
Department of Economics, Business and Statistical Science, Palermo, Italy.
4
Department of Psychology, University of Palermo, Palermo, Italy.
5
National Healthcare System, ASL TO3, Turin, Italy.
6
Allergy and Respiratory Diseases, Department of Internal Medicine, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.
PMID:
28218956
DOI:
10.1111/pai.12707
[Indexed for MEDLINE]
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19.
J Fam Pract. 2016 Dec;65(12):889-899.

Improving your approach to nasal obstruction.

Author information

1
Naval Hospital Camp Pendleton, CA, USA. Email: margaret.a.bayard.mil@mail.mil.
2
Naval Hospital Camp Pendleton, CA, USA.

Abstract

The causes are diverse--from rhinitis and rhinosinusitis to drugs and structural/mechanical abnormalities. Here's how to provide patients with relief.

PMID:
28149972
[Indexed for MEDLINE]
Icon for Frontline Medical Communications Inc
20.
Sci Rep. 2017 Jan 18;7:40425. doi: 10.1038/srep40425.

Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial.

Author information

1
Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Abstract

In the clinic, approximately 30% of children with adenoid hypertrophy (AH) concomitant with allergic rhinitis (AR) report poor responses to intranasal steroids. To determine whether the combination of mometasone furoate (MF) and oxymetazoline (OXY) is more effective than either agent alone, we performed a two-stage, parallel, randomized, double-blind, double-dummy, clinical trial with 240 AH children with concomitant perennial AR. During the first stage, all children were randomly assigned to the MF or control group for six weeks of treatment. During the second stage, the non-responders from stage one were randomly assigned to 4 groups for 8 weeks of treatment that involved receiving the following treatments: MF/OXY, MF/placebo, placebo/OXY, or placebo/placebo. During the first stage of treatment, 39% of the responders treated with MF achieved greater reductions in total and individual symptom scores than did those on placebo. During the second stage of treatment, the nasal congestion scores of the MF/OXY group significantly decreased. The adenoid/choana ratio of the MF/OXY-treated group decreased and the nasal volume increased significantly. Our results suggest that the combination of OXY and MF is effective and safe for the treatment of AH children with concomitant AR and has a rapid onset of action.

PMID:
28098165
PMCID:
PMC5241667
DOI:
10.1038/srep40425
[Indexed for MEDLINE]
Free PMC Article
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