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1.
Mutagenesis. 2018 Apr 13;33(2):129-135. doi: 10.1093/mutage/gex047.

Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.

Author information

1
Department of Genetics, Kemerovo State University, Russian Federation.
2
Department of Bionanotechnology, Kemerovo State University, Russian Federation.
3
Department of Occupational Pathology, Kemerovo Regional Clinical Hospital, Russian Federation.
4
Department for Occupational Pathology, Regional Clinical Center of Miners' Health, Russian Federation.
5
Research Institute for Complex Problems of Hygiene and Occupational Diseases, Russian Federation.
6
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences Russian Federation.
7
CSIR-National Environmental Engineering Research Institute, Nagpur, India.
8
Laboratory of Genetic Toxicology, Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Brazil.
9
Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, Brazil.

Abstract

Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI}, 3.29-4.10) and 0.28 (95% CI, 0.17-0.38)] compared to the control group [2.41 (95% CI, 2.00-2.82) and 0.09 (95% CI, 0.03-0.15)], respectively. IL1β gene T/T genotype (rs16944) was associated with AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88-12.15), P < 0.01]. A significant increase in the level of certain chromosome interchanges among AS donors is of interest because such effects are typical for radiation damage and caused by acute oxidative stress. IL1β T allele probably may be considered as an AS susceptibility factor among coal miners.

PMID:
29378067
DOI:
10.1093/mutage/gex047
[Indexed for MEDLINE]
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2.
Clin Nucl Med. 2017 Oct;42(10):e431-e432. doi: 10.1097/RLU.0000000000001782.

68Ga-PSMA-Ligand PET/CT Uptake in Anthracosilicosis.

Author information

1
From the *Department of Nuclear Medicine, Gold Coast University Hospital, Southport, Queensland Australia; †South Coast Radiology.

Abstract

This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT. Contrary to its name, PSMA is expressed in a number of other normal tissues and pathological states. Prostate-specific membrane antigen expression has been linked to tumor angiogenesis in various other epithelial neoplasms, as well as neovasculature associated with tissue regeneration and repair. Awareness of nonneoplastic inflammatory conditions associated with Ga-PSMA-ligand uptake aids in patient assessment and management.

PMID:
28806260
DOI:
10.1097/RLU.0000000000001782
[Indexed for MEDLINE]
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3.
Can Respir J. 2016;2016:9254374. doi: 10.1155/2016/9254374. Epub 2016 Jul 10.

Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis.

Author information

1
Division of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland.
2
Department of Rheumatology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland.
3
Department of Immunology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland.
4
Division of Pulmonology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland.

Abstract

BACKGROUND:

Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses.

CASE PRESENTATION:

We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer. Within a short period of time, pulmonary nodules grew rapidly. Thoracoscopically, the resected lung specimen revealed silicoanthracosis associated with small-to-medium-size vasculitis in the presence of antineutrophil cytoplasmatic autoantibodies (c-ANCA).

CONCLUSION:

Pulmonary silicoanthracotic lesions on the base of ANCA-associated vasculitis and CPPD arthritis can rapidly grow. A mutual correlation between silicoanthracosis, ANCA-associated vasculitis, and CPPD seems possible. Apart from this, consideration of metastatic disease should be obligatory in patients with a history of cancer at the same time being immunosuppressed.

PMID:
27478398
PMCID:
PMC4958431
DOI:
10.1155/2016/9254374
[Indexed for MEDLINE]
Free PMC Article
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4.
Med Tr Prom Ekol. 2016 Aug;(5):16-20.

Diagnostic features of atherosclerosis development in miners having anthracosilicosis.

[Article in English, Russian]

Abstract

To design forecasting system, the authors studied occurrence of atherosclerosis and its risk factors in 152 workers of coal mines in South Kouzbass (tunnellers, cleaning pit-face miners, mining excavator operators), suffering from anthracosilicosis. Atherosclerosis was revealed in 124 (81.6%) workers with anthracosilicosis. With Bayess method for independent signs and Wald's sequential analysis method, the authors created a way to forecast atherosclerosis with coronary, extracranial and peripheral arteries involvement in miners with anthracosilicosis. Maximal risk of atherosclerosis in miners with anthracosilicosis is associated with following parameters: age 45 years and over, arterial hypertension, smoking, abdominal obesity type, diabetes mellitus, metabolic syndrome, respiratory failure, family history of IHD, hypercholesterolemia, increased LDL cholesterol, decreased HDL cholesterol, increased atherogeneity coefficient, hypertriglyceridemia, hyperhomocysteinemia, hyperfibrinogenemia, increased C-reactive protein, hypersthenic type according to Reese-Isenc index, andromorphic type according to Tanner index, blood group. markers A (II) and B (III), rhesus negative, MN and NN. Through increased number of factors analyzed and selected additional markers, accuracy of atherosclerosis forecasting is increased - that enables to proceed with opportune treatment and prevention.

PMID:
30351698
[Indexed for MEDLINE]
5.
Med Tr Prom Ekol. 2016 Aug;(5):11-15.

Specificity of morphologic changes in target organs, associated with exposure to coal rock dust and fluorine compounds.

[Article in English, Russian]

Abstract

The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mostly in lungs and bronchi even on 6th week of the experiment. In liver, changes in parenchyma and stroma are controlled by reparative processes by 9th week. Accumulation of sodium fluoride in the body causes irreversible necrotic changes mostly in liver, on 6th week of the intoxication. With that, morphologic changes in lungs and bronchi are minor, characterized by immune inflammation with degenerative changes only after the 9th week. Irrespective of the acting hazard, vascular changes are characterized by media and intima hypertrophy with endothelial dystrophy and hyalinosis since the 6th week of the experiment.

PMID:
30351697
[Indexed for MEDLINE]
6.
Bull Exp Biol Med. 2015 Aug;159(4):431-4. doi: 10.1007/s10517-015-2983-9. Epub 2015 Sep 21.

Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development.

Author information

1
Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
2
Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia. nyura_g@mail.ru.

Abstract

Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes.

KEYWORDS:

HIF-1α; HSP family proteins; anthracosilicosis; free radical oxidation; myocardium

PMID:
26388578
DOI:
10.1007/s10517-015-2983-9
[Indexed for MEDLINE]
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7.
J Occup Environ Med. 2015 Jan;57(1):62-7. doi: 10.1097/JOM.0000000000000302.

Debilitating lung disease among surface coal miners with no underground mining tenure.

Author information

1
From the Surveillance Branch (Dr Halldin, Dr Petsonk, Ms Wolfe, Dr Storey, and Dr Laney), Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa; Office of Mine Safety and Health Research (Dr Reed, Mr Joy, Mr Colinet, and Mr Rider), National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, Penn; and Department of Pathology (Dr Abraham), State University of New York Upstate Medical University, Syracuse.

Abstract

OBJECTIVE:

To characterize exposure histories and respiratory disease among surface coal miners identified with progressive massive fibrosis from a 2010 to 2011 pneumoconiosis survey.

METHODS:

Job history, tenure, and radiograph interpretations were verified. Previous radiographs were reviewed when available. Telephone follow-up sought additional work and medical history information.

RESULTS:

Among eight miners who worked as drill operators or blasters for most of their tenure (median, 35.5 years), two reported poor dust control practices, working in visible dust clouds as recently as 2012. Chest radiographs progressed to progressive massive fibrosis in as few as 11 years. One miner's lung biopsy demonstrated fibrosis and interstitial accumulation of macrophages containing abundant silica, aluminum silicate, and titanium dust particles.

CONCLUSIONS:

Overexposure to respirable silica resulted in progressive massive fibrosis among current surface coal miners with no underground mining tenure. Inadequate dust control during drilling/blasting is likely an important etiologic factor.

PMID:
25563541
PMCID:
PMC4626873
DOI:
10.1097/JOM.0000000000000302
[Indexed for MEDLINE]
Free PMC Article
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8.
Med Tr Prom Ekol. 2014;(2):10-4.

[Contemporary features of pneumoconiosis formation and course in miners of East Donbass].

[Article in Russian]

Abstract

The author analyzed dynamics and structure of occupational morbidity including pneumoconiosis in Rostov region of Russian Federation, since 1990 until now. They were compared with analogous parameters of previous historical period. Findings are that contemporary dynamics of anthracosilicosis clinical features is characterized by severily reduced terms of the disease development from medical registration of the diseased miner, earlier addition of malignancy, respiratory failure and other complications--that in aggregate causes earlier disablement and drastically reduced survival rate in occupational patients with anthracosilicosis.

PMID:
25073334
[Indexed for MEDLINE]
9.
Diagn Cytopathol. 2014 Sep;42(9):759-65. doi: 10.1002/dc.23120. Epub 2014 Feb 18.

Calcareous concretions and psammoma bodies in sputum smears: do these similar structures have different clinical significance?

Author information

1
CFGS Anatomía Patológica y Citología, Instituto de Piedras Blancas, Asturias, Spain; Fundación INCLÍNICA, Oviedo, Spain.

Abstract

Different noncellular elements, such as round concentric calcified laminated structures, may be found in sputum smears. If these structures appear isolated on the background of the smear, the term usually used to describe them is "calcareous concretions" (CC). On the contrary, when the structures are part of epithelial cell groups or small tissue fragments, the term used to describe them is "Psammoma bodies" (PB). The aim of this work is to establish the relationship between these structures and pulmonary disease, especially lung carcinoma, by searching for the presence of CC and/or PB in sputum smears. Our study has taken as a basis 16.716 sputum smears from 696 patients obtained during a 7-year period (2003-2009). After reviewing them, it was found that from the total, 66 cases (0.39%) contained round calcified structures, 57 of them (0.34%) corresponding to CC, and the remaining 9 ones (0.05%) corresponding to PB. From these 57 CC cases, 56 corresponded to benign entities, and only one was found with lung carcinoma. On the other hand, from the 9 PB cases all of them (100%) were related to lung adenocarcinoma. We conclude that, even having a similar morphological structure, these aforementioned calcified structures we have observed in sputum smears have different and relevant clinical significance.

KEYWORDS:

Papanicolaou method; calcareous concretions; psammoma bodies; sputum smears

PMID:
24550186
DOI:
10.1002/dc.23120
[Indexed for MEDLINE]
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12.
Med Tr Prom Ekol. 2011;(2):15-21.

[Clinical and experimental studies of metabolic response to chronic exposure to coal dust].

[Article in Russian]

Abstract

In miners anthracosilicosis is caused by chronic exposure to coal dust and is characterized by progressive development of the inflammatory process, the expressed disorders of lipid metabolism, and immunodeficiency. In the experiment we revealed the stages of anthracosilicosis development according to which adequate measures of prevention and correction of the disorders caused by long exposure of an organism to coal dust are recommended.

PMID:
21506373
[Indexed for MEDLINE]
13.
Arch Bronconeumol. 2010 Oct;46(10):562-3. doi: 10.1016/j.arbres.2010.06.001. Epub 2010 Jul 16.

[Unusual exposure source in a patient with silicosis].

[Article in Spanish]
PMID:
20638170
DOI:
10.1016/j.arbres.2010.06.001
[Indexed for MEDLINE]
Free full text
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14.
Med Tr Prom Ekol. 2010;(5):31-6.

[Quantitative characteristics of pathomorphologic changes in bronchi and pulmonary artery branches in miners with preroentgenologic stage of anthrasilicosis].

[Article in Russian]

Abstract

Morphometric studies covered lung tissue of 10 miners exposed to dusty work conditions over 1 to 30 (13.4 +/- 3.6) years, who were considered apparently healthy according to follow-up examinations and died in technogenic accident. Findings are that dysregeneration, hypertrophic and sclerotic changes in respiratory part of lungs, in bronchi and in pulmonary circuit arteries develop simultaneously--that proves common pathogenetic concept of these changes and systemic character of the pneumoconiosis. The results necessitate improved methods to evaluate health state of workers, refined criteria for nosologic diagnosis of respiratory diseases related to dust.

PMID:
20635544
[Indexed for MEDLINE]
15.
Radiologia. 2010 Mar-Apr;52(2):185-6; author reply 186. doi: 10.1016/j.rx.2009.11.012. Epub 2010 Feb 24.

[Anthracosilicosis: a definitive diagnosis?].

[Article in Spanish]

Comment in

PMID:
20185155
DOI:
10.1016/j.rx.2009.11.012
[Indexed for MEDLINE]
Free full text
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16.
Rev Clin Esp. 2009 Sep;209(8):388-90.

[Patient with bilateral lung nodes like metastasis. Late silicosis].

[Article in Spanish]

Author information

1
Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, España. taniarmv@msm.com

Abstract

We present a 72-year-old patient that he has admitted to analize a large amount and bilateral lung nodes in a incidentally thorax x-ray. It is carried out a lung node biopsy, with a result of silicoanthacosis.

PMID:
19775587
DOI:
10.1016/s0014-2565(09)72342-2
[Indexed for MEDLINE]
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17.
Radiologia. 2009 Nov-Dec;51(6):601-4. doi: 10.1016/j.rx.2009.05.007. Epub 2009 Sep 3.

[Anthracosilicosis: a rare clinical and radiological presentation simulating lung metastases].

[Article in Spanish]

Author information

1
Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Madrid, España. noeliaarevalo@hotmail.com

Abstract

We present the case of an asymptomatic patient with an initial clinical and radiological diagnosis of lung metastases in whom histological study diagnosed anthracosilicosis. A review of the literature shows that this presentation of anthracosilicosis is exceptional; our patient had atypical radiological findings and a very long latency period (over 50 years) after a brief (nearly 6 years) exposure to coal dust.

PMID:
19732920
DOI:
10.1016/j.rx.2009.05.007
[Indexed for MEDLINE]
Free full text
Icon for Ediciones Doyma, S.L.
19.
Thorax. 2008 Jul;63(7):655-7. doi: 10.1136/thx.2006.070243.

Anthracofibrosis attributed to mixed mineral dust exposure: report of three cases.

Author information

1
Université Paris 13, EA2363, Hôpital Universitaire Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France. jean-marc.naccache@avc.ap-hop-paris.fr

Abstract

Anthracofibrosis, defined as bronchial luminal narrowing with black pigmentation of the overlying mucosa, has been attributed to tuberculosis. Three patients with anthracofibrosis without mycobacterial infection are described who had previous occupational exposure to mixed dusts. CT scans showed calcified hilar lymph nodes in two patients. Surgical biopsy in one patient and autopsy in another revealed fibrotic lymph nodes with black pigmentation. Mineralogical analysis by transmission electron microscopy of pulmonary, hilar and/or bronchial samples found high levels of particle retention, raised percentages of free crystalline silica and mica in two patients, and free crystalline silica, kaolin and other silicates in the third. No evidence of any other contributory factor was found, suggesting that mixed mineral dust was the most probable cause. These observations suggest that exposure to mixed mineral dust should be added to the aetiology of anthracofibrosis.

PMID:
18587036
DOI:
10.1136/thx.2006.070243
[Indexed for MEDLINE]
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20.
AJR Am J Roentgenol. 2008 Jul;191(1):247-51. doi: 10.2214/AJR.07.2161.

CT differentiation of anthracofibrosis from endobronchial tuberculosis.

Author information

1
Department of Radiology, Kangnam St. Mary's Hospital, College of Medicine, Catholic University of Korea, 505 Banpo-dong Seocho-gu, Seoul 137-040, South Korea.

Abstract

OBJECTIVE:

The purpose of this study was to use CT to differentiate anthracofibrosis from endobronchial tuberculosis (TB), both of which are major causes of benign bronchostenosis.

MATERIALS AND METHODS:

We retrospectively reviewed the clinical and CT findings of 49 patients with anthracofibrosis and 35 patients with endobronchial TB diagnosed on the basis of bronchoscopic, microbiologic, and pathologic findings. Forty-five patients with anthracofibrosis and 32 patients with endobronchial TB had bronchostenosis on CT and were enrolled in the analysis. Nine (20%) of 45 patients with anthracofibrosis had coexistent active TB (two, endobronchial TB; six, pulmonary TB; one, TB pleurisy), and 13 (29%) had pulmonary infections other than TB. Two patients with anthracofibrosis and coexistent endobronchial TB were excluded from the analysis. The CT findings were analyzed with emphasis on the pattern, distribution, and location of bronchostenosis and the number of pulmonary lobes involved.

RESULTS:

Anthracofibrosis was more common than endobronchial TB among elderly patients (p < 0.05). Statistically significant findings on CT were the pattern of bronchostenosis, presence of main bronchus involvement, and number of pulmonary lobes involved (p < 0.05). Bronchostenosis with anthracofibrosis usually involves multiple lobar or segmental bronchi. The main bronchus, however, tends to be preserved in anthracofibrosis. Most cases of endobronchial TB involve one lobar bronchus and the ipsilateral main bronchus with contiguity in extent.

CONCLUSION:

Anthracofibrosis can be differentiated from endobronchial TB on CT. Furthermore, CT is helpful in the diagnosis of anthracofibrosis before bronchoscopy is performed.

PMID:
18562754
DOI:
10.2214/AJR.07.2161
[Indexed for MEDLINE]
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