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Pathog Dis. 2015 Nov;73(8):ftv060. doi: 10.1093/femspd/ftv060. Epub 2015 Aug 26.

Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.

Author information

1
Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland.
2
Department of Intensive Care Medicine, Lausanne University Hospital Center (CHUV), CH-1011 Lausanne, Switzerland.
3
Department of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland jose.entenza@unil.ch.

Abstract

Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.

KEYWORDS:

Enterococcus faecalis; Streptococcus gallolyticus; antiplatelets; experimental endocarditis; prophylaxis

PMID:
26310867
PMCID:
PMC4626580
DOI:
10.1093/femspd/ftv060
[Indexed for MEDLINE]
Free PMC Article

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