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Epilepsy Behav. 2014 Aug;37:184-90. doi: 10.1016/j.yebeh.2014.06.034. Epub 2014 Jul 20.

Lateralization of olfactory processing: differential impact of right and left temporal lobe epilepsies.

Author information

1
Olfaction: From Coding to Memory Team, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, University of Lyon, France.
2
Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France; TIGER, Neuroscience Research Center of Lyon, INSERM U1028, CNRS 5292, Lyon-1 University, Lyon, France; Department of Clinical Neurosciences, CHUV, Lausanne, Swizterland.
3
Olfaction: From Coding to Memory Team, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, University of Lyon, France. Electronic address: royet@olfac.univ-lyon1.fr.

Abstract

Olfactory processes were reported to be lateralized. The purpose of this study was to further explore this phenomenon and investigate the effect of the hemispheric localization of epileptogenic foci on olfactory deficits in patients with temporal lobe epilepsy (TLE). Olfactory functioning was assessed in 61 patients and 60 healthy control (HC) subjects. The patients and HC subjects were asked to rate the intensity, pleasantness, familiarity, and edibility of 12 common odorants and then identify them. Stimulations were delivered monorhinally in the nostril ipsilateral to the epileptogenic focus in TLE and arbitrarily in either the left or the right nostril in the HC subjects. The results demonstrated that regardless of the side of stimulation, patients with TLE had reduced performance in all olfactory tasks compared with the HC subjects. With regard to the side of the epileptogenic focus, patients with left TLE judged odors as less pleasant and had more difficulty with identification than patients with right TLE, underlining a privileged role of the left hemisphere in the emotional and semantic processing of odors. Finally, irrespective of group, a tendency towards a right-nostril advantage for judging odor familiarity was found in agreement with a prominent role of the right hemisphere in odor memory processing.

KEYWORDS:

Lateralization; Olfaction; Temporal lobe epilepsy

PMID:
25048728
DOI:
10.1016/j.yebeh.2014.06.034
[Indexed for MEDLINE]

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