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Science. 1997 Nov 14;278(5341):1319-22.

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

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1
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0554, USA.

Abstract

The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16. daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.

PMID:
9360933
[Indexed for MEDLINE]
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