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Bone. 2019 Jul 26;127:544-555. doi: 10.1016/j.bone.2019.07.024. [Epub ahead of print]

A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration.

Author information

1
Department of Structural Mechanics, Berlin Institute of Technology, Fakultät V - Institut für Mechanik, FG Strukturmechanik und Strukturberechnung, Sekr. C 8-3, Geb. M Str. des 17, Juni 135, D-10623 Berlin, Germany. Electronic address: melika.mohammadkhah@tu-berlin.de.
2
Department of Structural Mechanics, Berlin Institute of Technology, Fakultät V - Institut für Mechanik, FG Strukturmechanik und Strukturberechnung, Sekr. C 8-3, Geb. M Str. des 17, Juni 135, D-10623 Berlin, Germany; Faculty of Mechanical Engineering, University of Nis, Aleksandra Medvedeva 14, 18000 Nis, Serbia. Electronic address: dragan.marinkovic@tu-berlin.de.
3
Department of Structural Mechanics, Berlin Institute of Technology, Fakultät V - Institut für Mechanik, FG Strukturmechanik und Strukturberechnung, Sekr. C 8-3, Geb. M Str. des 17, Juni 135, D-10623 Berlin, Germany. Electronic address: manfred.zehn@tu-berlin.de.
4
Department of Structural Mechanics, Berlin Institute of Technology, Fakultät V - Institut für Mechanik, FG Strukturmechanik und Strukturberechnung, Sekr. C 8-3, Geb. M Str. des 17, Juni 135, D-10623 Berlin, Germany; Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Föhrer Str. 15, 13353 Berlin, Germany. Electronic address: sara.checa@charite.de.

Abstract

Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical and electrical interactions that take place during these processes, several computer models have been developed and used to test hypothesis on potential mechanisms behind experimental observations. This paper aims to review the available literature on computer modeling of bone piezoelectricity and its application to bone adaptation and healing. We first provide a brief overview of the fundamentals of piezoelectricity and bone piezoelectric effects. We then review how these properties have been used in computational models of bone adaptation and electromechanical behaviour of bone. In addition, in the last section, we summarize current limitations and potential directions for future work.

KEYWORDS:

Bone adaptation and regeneration; Bone piezoelectricity; Computer model; Matrix piezoelectricity; Strain Generated Potentials (SGP); Streaming potential

PMID:
31356890
DOI:
10.1016/j.bone.2019.07.024

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