Format

Send to

Choose Destination
J Virol. 1985 Sep;55(3):836-9.

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.

Abstract

Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.

PMID:
2991600
PMCID:
PMC255070
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center