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Eur J Clin Nutr. 2018 Apr;72(4):504-510. doi: 10.1038/s41430-018-0116-z. Epub 2018 Mar 8.

The impact of malnutrition on quality of life in patients with systemic sclerosis.

Author information

1
Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
2
Charité Forschungsgruppe Geriatrie, corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
3
Klinik für Rheumatologie und klinische Immunologie, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
4
Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
5
Charité Forschungsgruppe Geriatrie, corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany. kristina.norman@charite.de.
6
Department of Nutrition and Gerontology, German Institute of Human Nutrition, Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. kristina.norman@charite.de.

Abstract

BACKGROUND/OBJECTIVES:

Our objective was to investigate the prevalence of malnutrition in patients with systemic sclerosis (SSc) and its impact on their quality of life (QoL).

SUBJECTS/METHODS:

One hundred and twenty-nine patients with SSc underwent clinical evaluation and were screened with the Malnutrition Universal Screening Tool (MUST). Malnutrition was defined as MUST score ≥2.To investigate QoL, all patients completed the Short Form 36 Questionnaire and the Scleroderma Health Assessment Questionnaire. The data were analyzed with IBM SPSS® Statistics by using χ2/Fisher's test, Mann-Whitney U test, correlation, and linear regression analysis.

RESULTS:

One hundred and twenty-nine patients were included in this study (mean age was 59.1 ± 13.8 years, 90.7% women). The prevalence of malnutrition was 10.9%. Age and disease duration were not significantly different between malnourished and well-nourished patients. All QoL scores (except bodily pain and self-reported health) were significantly impaired in malnourished patients. Furthermore, the Scleroderma Health Assessment Score score which assesses disease-specific QoL was significantly higher in the malnourished patients (1.6 ± 0.73 compared to 0.91 ± 0.61 in well-nourished patients; p = 0.001), reflecting a lower QoL due to disease-specific impairments.

CONCLUSIONS:

Severe malnutrition in SSc patients is associated with reduced QoL. Standardized nutritional screening should routinely be conducted to identify the risk of malnutrition in order to enable an intervention with multimodal treatment and avoid the serious consequences associated with severe malnutrition.

PMID:
29520082
DOI:
10.1038/s41430-018-0116-z
[Indexed for MEDLINE]

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