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Dev Neuropsychol. 2016 Jan-Mar;41(1-2):6-21. doi: 10.1080/87565641.2016.1164172. Epub 2016 Apr 13.

Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers.

Author information

1
a Department of Psychology , University College Dublin , Dublin , Ireland.
2
b Bioimaging, School of Medicine , Boston University , Boston , Massachusetts.
3
c Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences , Trinity College Dublin , Dublin , Ireland.
4
d Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.
5
e University Medical Centre Hamburg-Eppendorf , Hamburg , Germany.
6
h Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
7
f Department of Psychiatry , Universite de Montreal, CHU Ste Justine Hospital , Montreal , Canada.
8
g Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
9
u Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience , King's College London , London , United Kingdom.
10
i Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University , Mannheim , Germany.
11
j Neurospin, Commissariat à l'Energie Atomique , CEA-Saclay Center , Paris , France.
12
k Department of Psychiatry and Psychotherapy , University Medical Center Hamburg-Eppendorf (UKE) , Hamburg , Germany.
13
l Departments of Psychiatry and Psychology , University of Vermont , Burlington , Vermont.
14
m Sir Peter Mansfield Imaging Centre School of Physics and Astronomy , University of Nottingham , University Park , Nottingham , United Kingdom.
15
n Department of Psychiatry and Psychotherapy, Campus Charité Mitte , Charité, Universitätsmedizin Berlin , Berlin , Germany.
16
o Physikalisch-Technische Bundesanstalt (PTB) , Braunschweig and Berlin , Germany.
17
p Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn , Paris , France.
18
q Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Psychiatry Department 91G16, Orsay Hospital , Paris , France.
19
r Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry , University of Toronto , Toronto , Canada.
20
s Department of Psychiatry and Neuroimaging Center , Technische Universität Dresden , Dresden , Germany.
21
t Department of Psychiatry , Universite de Montreal, CHU Ste Justine Hospital , Montreal , Canada.

Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

PMID:
27074029
PMCID:
PMC5684700
DOI:
10.1080/87565641.2016.1164172
[Indexed for MEDLINE]
Free PMC Article

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