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J Med Virol. 1987 Oct;23(2):165-73.

Detection of flavivirus antibodies in human serum by epitope-blocking immunoassay.

Author information

1
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Abstract

Human flavivirus group-reactive, dengue complex-reactive, and encephalitis virus complex-reactive antibodies were detected using epitope-blocking immunoassays in which the binding of selected mouse monoclonal antibodies to flavivirus antigens was blocked by human serum. When late (greater than 6 months after illness) convalescent sera were tested, the epitope-blocking immunoassays were superior to the hemagglutination inhibition test and comparable to the plaque reduction neutralization for identifying subjects immune to dengue, to Japanese encephalitis, or both viruses.

PMID:
2445910
DOI:
10.1002/jmv.1890230209
[Indexed for MEDLINE]

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