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J Antimicrob Chemother. 1996 Oct;38(4):727-31.

The in-vitro anti-rickettsial activity of macrolides.

Author information

1
Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel. xiibr@weizmann.weizmann.ac.il

Abstract

The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of > or = 50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.

PMID:
8937968
DOI:
10.1093/jac/38.4.727
[Indexed for MEDLINE]

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