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Antimicrob Agents Chemother. 1979 Mar;15(3):368-71.

Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.

Abstract

The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.

PMID:
464562
PMCID:
PMC352667
DOI:
10.1128/aac.15.3.368
[Indexed for MEDLINE]
Free PMC Article

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