Format

Send to

Choose Destination
Eur J Clin Microbiol Infect Dis. 2018 Apr;37(4):587-604. doi: 10.1007/s10096-017-3112-7. Epub 2017 Oct 8.

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches.

Author information

1
Laboratoire d'Ecologie Microbienne, FSNV, Université de Bejaia, 06000, Bejaia, Algeria.
2
Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 186 Chemin du Carreau de Lanes, CS83021, 30908, Nîmes, France.
3
Department of Microbiology, University Hospital of Nîmes, Nîmes, France.
4
Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 186 Chemin du Carreau de Lanes, CS83021, 30908, Nîmes, France. jean.philippe.lavigne@chu-nimes.fr.
5
Department of Microbiology, University Hospital of Nîmes, Nîmes, France. jean.philippe.lavigne@chu-nimes.fr.

Abstract

The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences. To date, 11 OXA-48-like variants have been identified, with classical OXA-48 being the most widespread. These enzymes show high-level hydrolytic activity against penicillins and low-level hydrolysis towards carbapenems. Since the first description of the OXA-48 carbapenemase in Turkey, bacterial strains producing the enzyme have been extensively reported in nosocomial and community outbreaks in many parts of the word, particularly in the Mediterranean area and European countries. The rapid spread of Enterobacteriaceae producing OXA-48-like enzymes in different ecosystems has become a serious issue recently. The number of reservoirs for such organisms is increasing, not only in hospitals, but also in the community, among animals (e.g., livestock, companion animals, and wildlife) and in the environment. This review aims to summarize the main characteristics of the OXA-48-type carbapenemases, covering genetic and enzymatic traits, their epidemiology, clonality and associated genes, correlation with extended-spectrum β-lactamases (ESBLs) or plasmidic AmpC (pAmpC) in different bacterial species worldwide.

KEYWORDS:

Carbapenemase; Enterobacteriaceae; Environment; Niches; OXA-48-like; Persistence

PMID:
28990132
DOI:
10.1007/s10096-017-3112-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center