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Antimicrob Agents Chemother. 2015 Aug;59(8):5022-5. doi: 10.1128/AAC.00442-15. Epub 2015 May 26.

First Report of OXA-181-Producing Escherichia coli in China and Characterization of the Isolate Using Whole-Genome Sequencing.

Author information

1
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
2
Laboratory of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
3
Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
4
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.

Abstract

We report the first OXA-181-producing strain in China. blaOXA-181 was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. blaOXA-181 was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of blaOXA-181.

PMID:
26014927
PMCID:
PMC4505247
DOI:
10.1128/AAC.00442-15
[Indexed for MEDLINE]
Free PMC Article

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