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Emerg Infect Dis. 2015 Apr;21(4):650-4. doi: 10.3201/eid2104.141859.

Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs.

Abstract

To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21-120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs.

KEYWORDS:

PCR; PDCoV; coronavirus; gnotobiotic pigs; pathogenicity; pigs; porcine deltacoronavirus; strain OH-FD100; strain OH-FD22; strains; viruses

PMID:
25811229
PMCID:
PMC4378491
DOI:
10.3201/eid2104.141859
[Indexed for MEDLINE]
Free PMC Article

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