Format

Send to

Choose Destination
Emerg Infect Dis. 2014 Apr;20(4):560-72. doi: 10.3201/eid2004.131769.

Novel betacoronavirus in dromedaries of the Middle East, 2013.

Abstract

In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.

KEYWORDS:

DcCoV; DcCoVUAE-HKU23; Dubai; MERS-CoV; Middle East; Middle East respiratory syndrome coronavirus; United Arab Emirates; betacoronavirus; camel; camel coronavirus; coronavirus; dromedaries; dromedary; dromedary camel coronavirus UAE-HKU23; dromedary coronavirus; viruses; zoonoses

PMID:
24655427
PMCID:
PMC3966378
DOI:
10.3201/eid2004.131769
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center