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Front Cell Infect Microbiol. 2013 Dec 24;3:106. doi: 10.3389/fcimb.2013.00106. eCollection 2013.

Yersinia pestis: mechanisms of entry into and resistance to the host cell.

Author information

1
Institute of Disease Control and Prevention, Academy of Military Medical Sciences Beijing, China ; Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences Beijing, China.
2
Institute of Disease Control and Prevention, Academy of Military Medical Sciences Beijing, China.
3
Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences Beijing, China.

Abstract

During infection, Yersinia, a facultative intracellular bacterial species, exhibits the ability to first invade host cells and then counteract phagocytosis by the host cells. During these two distinct stages, invasion or antiphagocytic factors assist bacteria in manipulating host cells to accomplish each of these functions; however, the mechanism through which Yersinia regulates these functions during each step remains unclear. Here, we discuss those factors that seem to function reversely and give some hypothesis about how bacteria switch between the two distinct status.

KEYWORDS:

T3SS; anti-phagocytosis; intracellular survival; invasion

PMID:
24400226
PMCID:
PMC3871965
DOI:
10.3389/fcimb.2013.00106
[Indexed for MEDLINE]
Free PMC Article

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