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Emerg Infect Dis. 2014 Jan;20(1):114-7. doi: 10.3201/eid2001.130353.

Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease.

Abstract

We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.

KEYWORDS:

CJD; Creutzfeldt-Jakob disease; TSE; blood; infectivity; prions; sCJD; transmissible spongiform encephalopathy; vCJD

PMID:
24377668
PMCID:
PMC3884712
DOI:
10.3201/eid2001.130353
[Indexed for MEDLINE]
Free PMC Article

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