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Antimicrob Agents Chemother. 2013 Apr;57(4):1965-7. doi: 10.1128/AAC.01297-12. Epub 2013 Jan 28.

Complete sequence of the IncT-type plasmid pT-OXA-181 carrying the blaOXA-181 carbapenemase gene from Citrobacter freundii.

Author information

1
Department of Infectious, Istituto Superiore di Sanità, Rome, Italy.

Abstract

The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and blaOXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene.

PMID:
23357767
PMCID:
PMC3623325
DOI:
10.1128/AAC.01297-12
[Indexed for MEDLINE]
Free PMC Article

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