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Hematol Oncol Clin North Am. 2013 Feb;27(1):89-99, viii. doi: 10.1016/j.hoc.2012.11.002. Epub 2012 Nov 22.

Chronic granulomatous disease.

Author information

1
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3-4141, MSC 1684, Bethesda, MD 20892-1684, USA. smh@nih.gov

Abstract

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation for nonmalignant diseases. Therefore, CGD is worthy of attention for its historical interest and because it is a disease for which expert management is imperative.

PMID:
23351990
PMCID:
PMC3558921
DOI:
10.1016/j.hoc.2012.11.002
[Indexed for MEDLINE]
Free PMC Article

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