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J Clin Microbiol. 2013 Jan;51(1):369-72. doi: 10.1128/JCM.02234-12. Epub 2012 Nov 14.

Emergence of OXA-48 and OXA-181 carbapenemases among Enterobacteriaceae in South Africa and evidence of in vivo selection of colistin resistance as a consequence of selective decontamination of the gastrointestinal tract.

Author information

1
Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa. brinka@ampath.co.za

Abstract

This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistant OXA-181-producing Klebsiella pneumoniae isolate was documented following selective digestive tract decontamination with oral colistin, which is therefore strongly discouraged.

PMID:
23152549
PMCID:
PMC3536210
DOI:
10.1128/JCM.02234-12
[Indexed for MEDLINE]
Free PMC Article

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