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Gend Med. 2012 Dec;9(6):463-70. doi: 10.1016/j.genm.2012.10.009. Epub 2012 Nov 7.

Does sex affect 30-day mortality in Staphylococcus aureus bacteremia?

Author information

1
Pharmacy Services, Rabin Medical Center, Beilinson Hospital, and Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel. narimanm@clalit.org.il

Abstract

BACKGROUND:

Sex-related differences in complications and mortality of infection were examined with conflicting results. Further studies are required to bring new light in this topic in Staphylococcus aureus infections.

OBJECTIVE:

We examined the outcomes of S. aureus infection in men and in women and whether sex-related differences were explained by underlying disorders, severity of disease, or clinical management.

METHODS:

This cohort study was conducted in a single center between 1988 and 2007. Patients with clinically significant S. aureus bacteremia were included. We compared 30-day all-cause mortality in men and women. We used multivariable logistic regression analysis to test whether sex was independently associated with mortality.

RESULTS:

One thousand ninety-three patients were identified with S. aureus bacteremia. All-cause mortality at day 30 was 39.3% (508 of 1293 patients): 44.8% (238 of 531 patients) in women and 35.4% (270 of 762 patients) in men (P < 0.01). In a multivariate analysis, female sex was associated with higher mortality (odds ratio = 1.63; 95% CI, 1.07-2.47). The excess mortality in women was not explained by differences in demographic characteristic factors, background conditions, infection severity and management, or septic complications.

CONCLUSIONS:

We found that women with S. aureus bacteremia had a greater risk of 30-day all-cause mortality than men, even when adjusting for other risk factors. However, we failed to explain this excess of mortality.

PMID:
23141419
DOI:
10.1016/j.genm.2012.10.009
[Indexed for MEDLINE]

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