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Transfus Apher Sci. 2010 Dec;43(3):387-391. doi: 10.1016/j.transci.2010.09.003. Epub 2010 Nov 11.

The risk of transmitting prion disease by blood or plasma products.

Author information

1
UK National CJD Surveillance Unit, University of Edinburgh, United Kingdom. Electronic address: R.Knight@ed.ac.uk.

Abstract

Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt-Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration.

PMID:
21071277
DOI:
10.1016/j.transci.2010.09.003
[Indexed for MEDLINE]

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