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Nano Lett. 2010 Nov 10;10(11):4727-31. doi: 10.1021/nl103210p.

High-throughput detection and sizing of individual low-index nanoparticles and viruses for pathogen identification.

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Department of Biomedical Engineering, Boston University, 44 Cummington Street, Fourth Floor, Boston, Massachusetts 02215, United States.


Rapid, chip-scale, and cost-effective single particle detection of biological agents is of great importance to human health and national security. We report real-time, high-throughput detection and sizing of individual, low-index polystyrene nanoparticles and H1N1 virus. Our widefield, common path interferometer detects nanoparticles and viruses over a very large sensing area, orders of magnitude larger than competing techniques. We demonstrate nanoparticle detection and sizing down to 70 nm in diameter. We clearly size discriminate nanoparticles with diameters of 70, 100, 150, and 200 nm. We also demonstrate detection and size characterization of hundreds of individual H1N1 viruses in a single experiment.

[Indexed for MEDLINE]

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