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J Clin Microbiol. 2009 Feb;47(2):459-62. doi: 10.1128/JCM.01181-08. Epub 2008 Dec 10.

Diagnosis of human immunodeficiency virus type 1 infection in infants by use of dried blood spots and an ultrasensitive p24 antigen assay.

Author information

1
Department Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA.

Abstract

We tested 617 dried blood spots (DBS) from human immunodeficiency virus-exposed infants from five countries using an ultrasensitive p24 antigen assay (Up24). The sensitivity was 94.4% (67/71) and the specificity was 100% (431/431) for infants with DBS specimens <or=20 months old; DBS older than 30 months demonstrated only 72.2% sensitivity (39/54) (P < 0.001) but displayed 100% specificity (61/61).

PMID:
19073872
PMCID:
PMC2643698
DOI:
10.1128/JCM.01181-08
[Indexed for MEDLINE]
Free PMC Article

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