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J Clin Microbiol. 2007 Aug;45(8):2723-5. Epub 2007 Jun 20.

Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae.

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1
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Mail Stop G-08, 1600 Clifton Road NE, Atlanta, GA 30333, USA. ebi2@cdc.gov

Abstract

The Klebsiella pneumoniae carbapenem (KPC) beta-lactamase occurs in Enterobacteriaceae and can confer resistance to all beta-lactam agents including carbapenems. The enzyme may confer low-level carbapenem resistance, and the failure of susceptibility methods to identify this resistance has been reported. Automated and nonautomated methods for carbapenem susceptibility were evaluated for identification of KPC-mediated resistance. Ertapenem was a more sensitive indicator of KPC resistance than meropenem and imipenem independently of the method used. Carbapenemase production could be confirmed with the modified Hodge test.

PMID:
17581941
PMCID:
PMC1951220
DOI:
10.1128/JCM.00015-07
[Indexed for MEDLINE]
Free PMC Article
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