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Antimicrob Agents Chemother. 2007 Aug;51(8):2855-60. Epub 2007 Apr 30.

Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland.

Author information

1
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, Bicêtre, France.

Abstract

The epidemiology of clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) was investigated among infection-associated enterobacterial isolates at the University Hospital in Lausanne, Switzerland, from January 2004 to June 2005. Out of 57 nonrepetitive ESBL producers (prevalence rate of 0.7%), 45 produced CTX-M-like ESBLs. CTX-M enzymes were mostly from clonally nonrelated Escherichia coli isolates, from urinary infections and community-acquired infections. Pediatric patients (20 out of 57) accounted for a large number of CTX-M producers. CTX-M-15 was the most frequent CTX-M-type enzyme. The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland.

PMID:
17470647
PMCID:
PMC1932552
DOI:
10.1128/AAC.01614-06
[Indexed for MEDLINE]
Free PMC Article

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