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Med Princ Pract. 2006;15(3):235-7.

Disseminated Penicillium marneffei infection with fungemia and endobronchial disease in an AIDS patient in China.

Author information

1
Department of Infectious Diseases, West China Hospital, Sichuan University, People's Republic of China. mishle333@yahoo.com

Abstract

OBJECTIVE:

To present a rare Chinese case of disseminated Penicillium marneffei infection with fungemia and endobronchial disease in an AIDS patient.

CLINICAL PRESENTATION AND INTERVENTION:

A 26-year-old policeman who had resided in Guangxi Province, China, for 3 years presented to his county hospital with a 2-month history of high fever and cough. A provisional diagnosis of pulmonary tuberculosis (TB) was made. Accordingly, the patient was treated with anti-TB drugs for 1 month but with no clinical improvement; he was then referred to West China Hospital. Blood and bone marrow cultures as well as a bronchoscopic biopsy were positive for P. marneffei. A confirmatory serologic test for HIV was positive. A combination therapy with amphotericin B and itraconazole was instituted, and the patient responded well to treatment.

CONCLUSION:

This case shows endobronchial involvement caused by an emerging fungal microorganism. HIV-positive patients with a history of residence in or travel to southern China and a clinical presentation suggestive of TB but responding poorly to anti-TB treatment may have P. marneffei infection.

PMID:
16651843
DOI:
10.1159/000092189
[Indexed for MEDLINE]
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