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Ophthalmic Epidemiol. 2005 Aug;12(4):223-32.

Uveal and conjunctival malignant melanoma in Denmark, 1943-97: incidence and validation study.

Author information

1
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. isager@dadlnet.dk

Abstract

PURPOSE:

To study the incidence of malignant melanoma in the ocular region in Denmark during the period 1943-97.

METHODS:

The patients were mainly identified through the Danish Cancer Registry. Age-period-cohort modelling of the incidence rates was done based on age at diagnosis, calendar period and birth cohort in 5-year groups and for each gender.

RESULTS:

The age-standardized incidence of malignant melanoma in the ocular region was 0.78 for men (N = 1327) and 0.65 for women (N = 1242) per 100,000 person-years. Calendar period and birth cohort had no effect on the incidence in the ocular region or in the topography subgroups choroid/ciliary body and conjunctiva. However, the incidence increased with birth cohort for iris melanomas.

CONCLUSIONS:

The incidence of malignant melanoma in the ocular region was stable in contrast to a major increase in cutaneous melanoma in Denmark during the period 1943-97. The incidence of iris melanomas increased substantially, whereas the rate was stable for choroid/ciliary body and conjunctival melanomas.

PMID:
16033743
DOI:
10.1080/09286580591000836
[Indexed for MEDLINE]

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