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Antimicrob Agents Chemother. 2003 Jun;47(6):2040-2.

Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis.

Author information

1
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

The Sterne and Ames strains of Bacillus anthracis carry chromosomal genes bla1 and bla2, which confer beta-lactam resistance when expressed in Escherichia coli. MIC measurements and steady-state kinetic analyses indicate that Bla1 possesses penicillinase activity while Bla2 possesses penicillinase, cephalosporinase, and carbapenem-hydrolyzing activities.

PMID:
12760895
PMCID:
PMC155864
DOI:
10.1128/aac.47.6.2040-2042.2003
[Indexed for MEDLINE]
Free PMC Article

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