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Genes Chromosomes Cancer. 2001 Dec;32(4):390-1.

Novel germline RET mutation segregating with papillary thyroid carcinomas.

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Laboratoire de Biologie Cellulaire et Hormonale, Hôpital A. de Villeneuve, CHU de Montpellier, Montpellier, France.


The RET proto-oncogene is responsible for inherited medullary thyroid cancer syndromes. RET is also found mutated in sporadic medullary thyroid cancer (MTC) and rearranged in sporadic papillary thyroid carcinomas. Here, we describe a previously unreported germline RET mutation at codon 603 in exon 10 associated with both MTC and nonmedullary thyroid cancer (NMTC) in a kindred. RET may thus not be excluded as a potential candidate for predisposition to some forms of NMTC.

[Indexed for MEDLINE]

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