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Ophthalmology. 2003 May;110(5):956-61.

Incidence of uveal melanoma in the United States: 1973-1997.

Author information

1
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

PURPOSE:

To determine the incidence of primary uveal melanoma in the United States over a 25-year period from 1973 to 1997.

DESIGN:

Systematic review of existing databases.

PARTICIPANTS:

Two thousand four hundred ninety-three patients with primary uveal melanoma (International Classification of Oncology [ICDO-2] codes C69.3 [choroid melanoma] and C69.4 [ciliary body and iris]) derived from the Surveillance, Epidemiology, and End Results (SEER) program database in the United States from 1973 to 1997.

METHODS:

The significance of trend in age-adjusted incidence rate was determined using chi-square test, and 95% confidence intervals were calculated.

MAIN OUTCOME MEASURES:

The age-adjusted incidence rate.

RESULTS:

There was a total of 2493 cases of uveal melanoma, representing 2.9% of all recorded cases of melanoma. Almost all cases (99.4%) were reported by the hospitals, and histopathologic confirmation was available in 81.3% of cases. The mean age-adjusted incidence of uveal melanoma in the United States was 4.3 per million (4.1-4.5; 95% confidence interval [CI]). Most cases (97.8%) occurred in the white population. There was significant variation of incidence between genders (males, 4.9 [4.6-5.2] 95% CI interval; females, 3.7 [3.5-3.9] 95% CI interval). There was no significant variation of incidence by the geographic location of the registry and over the entire period of observation (chi-square test).

CONCLUSIONS:

The mean age-adjusted incidence of uveal melanoma (4.3 per million) in the United States is similar to that reported from European countries. The age-adjusted incidence rate of uveal melanoma has remained stable for the past 25 years.

PMID:
12750097
DOI:
10.1016/S0161-6420(03)00078-2
[Indexed for MEDLINE]

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