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Items: 1 to 20 of 92

1.

Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes.

Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL.

Stem Cell Reports. 2018 Sep 11;11(3):626-634. doi: 10.1016/j.stemcr.2018.07.012. Epub 2018 Aug 23.

2.

Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy.

Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL.

Ann Clin Transl Neurol. 2018 Jul 5;5(8):982-987. doi: 10.1002/acn3.599. eCollection 2018 Aug.

3.

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.

Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG.

Elife. 2018 Aug 14;7. pii: e37610. doi: 10.7554/eLife.37610.

4.

Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology.

Edokobi N, Isom LL.

Front Physiol. 2018 Apr 23;9:351. doi: 10.3389/fphys.2018.00351. eCollection 2018. Review.

5.

Opposing Phenotypes in Dravet Syndrome Patient-Derived Induced Pluripotent Stem Cell Neurons: Can Everyone Be Right?

Isom LL.

Epilepsy Curr. 2017 Jul-Aug;17(4):244-247. doi: 10.5698/1535-7597.17.4.244. No abstract available.

6.

Voltage-Gated Sodium Channel β Subunits and Their Related Diseases.

Bouza AA, Isom LL.

Handb Exp Pharmacol. 2018;246:423-450. doi: 10.1007/164_2017_48. Review.

PMID:
28965169
7.

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease.

Hull JM, Isom LL.

Neuropharmacology. 2018 Apr;132:43-57. doi: 10.1016/j.neuropharm.2017.09.018. Epub 2017 Sep 18. Review.

PMID:
28927993
8.

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.

Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O'Malley HA, Meisler MH, Isom LL.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2383-2388. doi: 10.1073/pnas.1616821114. Epub 2017 Feb 13.

9.

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL.

Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e003923.

10.

Expecting the Unexpected: Lack of In Vivo Network Defects in an Scn1a Model of Dravet Syndrome.

Hull JM, Isom LL.

Epilepsy Curr. 2016 Nov-Dec;16(6):408-410. No abstract available.

11.

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy.

Frasier CR, Wagnon JL, Bao YO, McVeigh LG, Lopez-Santiago LF, Meisler MH, Isom LL.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12838-12843. doi: 10.1073/pnas.1612746113. Epub 2016 Oct 26.

12.

Developmental and Regulatory Functions of Na(+) Channel Non-pore-forming β Subunits.

Winters JJ, Isom LL.

Curr Top Membr. 2016;78:315-51. doi: 10.1016/bs.ctm.2016.07.003. Epub 2016 Aug 2. Review.

PMID:
27586289
13.

Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent.

Caballero-Florán RN, Conde-Rojas I, Oviedo Chávez A, Cortes-Calleja H, Lopez-Santiago LF, Isom LL, Aceves J, Erlij D, Florán B.

Neuropharmacology. 2016 Nov;110(Pt A):407-418. doi: 10.1016/j.neuropharm.2016.08.002. Epub 2016 Aug 6.

PMID:
27506997
14.

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function.

Kruger LC, O'Malley HA, Hull JM, Kleeman A, Patino GA, Isom LL.

J Neurosci. 2016 Jun 8;36(23):6213-24. doi: 10.1523/JNEUROSCI.0405-16.2016.

15.

Voltage-Gated Na+ Channels: Not Just for Conduction.

Kruger LC, Isom LL.

Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6). pii: a029264. doi: 10.1101/cshperspect.a029264. Review.

16.

Role of Sodium Channels in Epilepsy.

Kaplan DI, Isom LL, Petrou S.

Cold Spring Harb Perspect Med. 2016 Jun 1;6(6). pii: a022814. doi: 10.1101/cshperspect.a022814. Review.

17.

Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit.

Offord J, Isom LL.

Crit Rev Biochem Mol Biol. 2015 Jul-Aug;51(4):246-56. doi: 10.3109/10409238.2016.1173010. Epub 2016 Apr 25. Review.

PMID:
27112431
18.

Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.

Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M.

Nat Commun. 2015 Nov 6;6:8803. doi: 10.1038/ncomms9803.

20.

Sodium channel β subunits: emerging targets in channelopathies.

O'Malley HA, Isom LL.

Annu Rev Physiol. 2015;77:481-504. doi: 10.1146/annurev-physiol-021014-071846. Review.

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