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Items: 1 to 20 of 117


Choice of test stimulus matters for pitch matching performance: Comparison between pure tone and narrow band noise.

Wollbrink A, Dobel C, Salvari V, Paraskevopoulos E, Kisker C, Mittmann K, Pantev C.

Hear Res. 2019 Sep 15;381:107776. doi: 10.1016/j.heares.2019.107776. Epub 2019 Aug 2.


Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.

Sauer F, Klemm T, Kollampally RB, Tessmer I, Nair RK, Popov N, Kisker C.

Mol Cell. 2019 May 2;74(3):421-435.e10. doi: 10.1016/j.molcel.2019.02.029. Epub 2019 Mar 26.


Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis.

Nasir N, Kisker C.

DNA Repair (Amst). 2019 Feb;74:17-25. doi: 10.1016/j.dnarep.2018.12.006. Epub 2018 Dec 26.


Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis.

Ramirez YA, Adler TB, Altmann E, Klemm T, Tiesmeyer C, Sauer F, Kathman SG, Statsyuk AV, Sotriffer C, Kisker C.

ChemMedChem. 2018 Oct 8;13(19):2014-2023. doi: 10.1002/cmdc.201800364. Epub 2018 Sep 6.


Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.


Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.

Grabarczyk DB, Silkenat S, Kisker C.

Structure. 2018 Jan 2;26(1):137-144.e3. doi: 10.1016/j.str.2017.11.004. Epub 2017 Dec 7.


Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458. doi: 10.1073/pnas.1711543114. Epub 2017 Dec 5.


The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C.

Nucleic Acids Res. 2017 Oct 13;45(18):10872-10883. doi: 10.1093/nar/gkx743.


Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.

Bartossek T, Jones NG, Schäfer C, Cvitković M, Glogger M, Mott HR, Kuper J, Brennich M, Carrington M, Smith AS, Fenz S, Kisker C, Engstler M.

Nat Microbiol. 2017 Nov;2(11):1523-1532. doi: 10.1038/s41564-017-0013-6. Epub 2017 Sep 11.


Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

Lu R, Schaefer CM, Nesbitt NM, Kuper J, Kisker C, Sampson NS.

ACS Infect Dis. 2017 Sep 8;3(9):666-675. doi: 10.1021/acsinfecdis.7b00072. Epub 2017 Aug 16.


The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.

Kaiser S, Sauer F, Kisker C.

Nat Commun. 2017 Jun 27;8:15907. doi: 10.1038/ncomms15907.


Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.

Fischer A, Harrison KS, Ramirez Y, Auer D, Chowdhury SR, Prusty BK, Sauer F, Dimond Z, Kisker C, Hefty PS, Rudel T.

Elife. 2017 Mar 28;6. pii: e21465. doi: 10.7554/eLife.21465.


Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ.

Biochemistry. 2017 Apr 4;56(13):1865-1878. doi: 10.1021/acs.biochem.6b01048. Epub 2017 Mar 21.


Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.

Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ.

J Am Chem Soc. 2017 Mar 8;139(9):3417-3429. doi: 10.1021/jacs.6b11148. Epub 2017 Feb 22.


OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.

Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.

Oncogene. 2017 Apr 6;36(14):1911-1924. doi: 10.1038/onc.2016.354. Epub 2016 Oct 17.


Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.

Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ.

Chem Sci. 2016 Sep 1;7(9):5945-5954. Epub 2016 May 25.


Different promoter affinities account for specificity in MYC-dependent gene regulation.

Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.

Elife. 2016 Jul 27;5. pii: e15161. doi: 10.7554/eLife.15161.


Conservation and Divergence in Nucleotide Excision Repair Lesion Recognition.

Wirth N, Gross J, Roth HM, Buechner CN, Kisker C, Tessmer I.

J Biol Chem. 2016 Sep 2;291(36):18932-46. doi: 10.1074/jbc.M116.739425. Epub 2016 Jul 12.


Role of XPD in cellular functions: To TFIIH and beyond.

Houten BV, Kuper J, Kisker C.

DNA Repair (Amst). 2016 Aug;44:136-142. doi: 10.1016/j.dnarep.2016.05.019. Epub 2016 May 16. Review.


Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Neckles C, Pschibul A, Lai CT, Hirschbeck M, Kuper J, Davoodi S, Zou J, Liu N, Pan P, Shah S, Daryaee F, Bommineni GR, Lai C, Simmerling C, Kisker C, Tonge PJ.

Biochemistry. 2016 May 31;55(21):2992-3006. doi: 10.1021/acs.biochem.5b01301. Epub 2016 May 17.

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