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Items: 1 to 20 of 62

1.

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity.

Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG.

Immunity. 2018 Oct 16;49(4):678-694.e5. doi: 10.1016/j.immuni.2018.08.002. Epub 2018 Oct 9.

PMID:
30314757
2.

CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.

Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y.

J Immunol. 2018 Aug 15;201(4):1174-1185. doi: 10.4049/jimmunol.1800659. Epub 2018 Jul 9.

PMID:
29987160
3.

A CD103+ Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis.

Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, Lavine KJ, Husain M, Brooks DG, Robbins CS, Cybulsky M, Epelman S.

Immunity. 2017 Nov 21;47(5):974-989.e8. doi: 10.1016/j.immuni.2017.10.011.

4.

Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming.

Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M.

AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S59-S69. doi: 10.1089/aid.2017.0161.

5.

Type I Interferon in Chronic Virus Infection and Cancer.

Snell LM, McGaha TL, Brooks DG.

Trends Immunol. 2017 Aug;38(8):542-557. doi: 10.1016/j.it.2017.05.005. Epub 2017 May 31. Review.

PMID:
28579323
6.

Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.

Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, Carrillo M, Martin H, Kasparian S, Syed P, Rice N, Brooks DG, Kitchen SG.

J Clin Invest. 2017 Jan 3;127(1):260-268. doi: 10.1172/JCI89488. Epub 2016 Dec 12.

7.

Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection.

Snell LM, Osokine I, Yamada DH, De la Fuente JR, Elsaesser HJ, Brooks DG.

Cell Rep. 2016 Sep 20;16(12):3286-3296. doi: 10.1016/j.celrep.2016.08.065.

8.

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.

Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG.

PLoS Pathog. 2016 Jan 25;12(1):e1005356. doi: 10.1371/journal.ppat.1005356. eCollection 2016 Jan.

9.

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.

10.

LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.

Walsh NC, Waters LR, Fowler JA, Lin M, Cunningham CR, Brooks DG, Rehg JE, Morse HC 3rd, Teitell MA.

EMBO Rep. 2015 Jun;16(6):753-68. doi: 10.15252/embr.201439505. Epub 2015 Apr 26.

11.

New insights into type I interferon and the immunopathogenesis of persistent viral infections.

Snell LM, Brooks DG.

Curr Opin Immunol. 2015 Jun;34:91-8. doi: 10.1016/j.coi.2015.03.002. Epub 2015 Mar 13. Review.

12.

Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection.

Yamada DH, Elsaesser H, Lux A, Timmerman JM, Morrison SL, de la Torre JC, Nimmerjahn F, Brooks DG.

Immunity. 2015 Feb 17;42(2):379-390. doi: 10.1016/j.immuni.2015.01.005. Epub 2015 Feb 10.

13.

Rapid detection of Mycobacterium tuberculosis by recombinase polymerase amplification.

Boyle DS, McNerney R, Teng Low H, Leader BT, Pérez-Osorio AC, Meyer JC, O'Sullivan DM, Brooks DG, Piepenburg O, Forrest MS.

PLoS One. 2014 Aug 13;9(8):e103091. doi: 10.1371/journal.pone.0103091. eCollection 2014.

14.

Decoding the complexity of type I interferon to treat persistent viral infections.

Wilson EB, Brooks DG.

Trends Microbiol. 2013 Dec;21(12):634-40. doi: 10.1016/j.tim.2013.10.003. Epub 2013 Nov 8. Review.

15.

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.

Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4.

16.

Discovery of novel drugs for promising targets.

Martell RE, Brooks DG, Wang Y, Wilcoxen K.

Clin Ther. 2013 Sep;35(9):1271-81. doi: 10.1016/j.clinthera.2013.08.005. Review.

PMID:
24054704
17.

Interfering with type I interferon: a novel approach to purge persistent viral infection.

Wilson EB, Brooks DG.

Cell Cycle. 2013 Sep 15;12(18):2919-20. doi: 10.4161/cc.26175. Epub 2013 Aug 23. No abstract available.

18.

Networking at the level of host immunity: immune cell interactions during persistent viral infections.

Ng CT, Snell LM, Brooks DG, Oldstone MB.

Cell Host Microbe. 2013 Jun 12;13(6):652-64. doi: 10.1016/j.chom.2013.05.014. Review.

19.

Blockade of chronic type I interferon signaling to control persistent LCMV infection.

Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ, Karp CL, Brooks DG.

Science. 2013 Apr 12;340(6129):202-7. doi: 10.1126/science.1235208.

20.

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.

Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ.

Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7.

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