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Items: 1 to 20 of 198


Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.

Perreault M, Wunsch E, Białek A, Trottier J, Verreault M, Caron P, Poirier GG, Milkiewicz P, Barbier O.

Can J Gastroenterol Hepatol. 2018 Apr 11;2018:8096314. doi: 10.1155/2018/8096314. eCollection 2018.


N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models.

Cieślak A, Trottier J, Verreault M, Milkiewicz P, Vohl MC, Barbier O.

Can J Gastroenterol Hepatol. 2018 Apr 5;2018:6031074. doi: 10.1155/2018/6031074. eCollection 2018.


Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage.

Collino A, Termanini A, Nicoli P, Diaferia G, Polletti S, Recordati C, Castiglioni V, Caruso D, Mitro N, Natoli G, Ghisletti S.

PLoS Genet. 2018 May 7;14(5):e1007380. doi: 10.1371/journal.pgen.1007380. eCollection 2018 May.


Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.

Gao X, Wang C, Ning C, Liu K, Wang X, Liu Z, Sun H, Ma X, Sun P, Meng Q.

Food Funct. 2018 May 23;9(5):2684-2694. doi: 10.1039/c8fo00107c.


Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro.

Gao X, Fu T, Wang C, Ning C, Liu K, Liu Z, Sun H, Ma X, Huo X, Yang X, Zou M, Meng Q.

Toxicol Appl Pharmacol. 2018 Jun 1;348:105-116. doi: 10.1016/j.taap.2018.04.015. Epub 2018 Apr 14.


Metabolism of Oxo-Bile Acids and Characterization of Recombinant 12α-Hydroxysteroid Dehydrogenases from Bile Acid 7α-Dehydroxylating Human Gut Bacteria.

Doden H, Sallam LA, Devendran S, Ly L, Doden G, Daniel SL, Alves JMP, Ridlon JM.

Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18. doi: 10.1128/AEM.00235-18. Print 2018 May 15.


Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity.

Kong Y, Gao X, Wang C, Ning C, Liu K, Liu Z, Sun H, Ma X, Sun P, Meng Q.

Eur J Pharmacol. 2018 Apr 5;824:64-71. doi: 10.1016/j.ejphar.2018.02.002. Epub 2018 Feb 7.


Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts.

Wang A, Yu D, Gong Y, Garber J, Minuk GY.

J Clin Exp Hepatol. 2017 Dec;7(4):316-320. doi: 10.1016/j.jceh.2017.04.002. Epub 2017 May 13.


The pathophysiology of human obstructive cholestasis is mimicked in cholestatic Gold Syrian hamsters.

van Golen RF, Olthof PB, de Haan LR, Coelen RJ, Pechlivanis A, de Keijzer MJ, Weijer R, de Waart DR, van Kuilenburg ABP, Roelofsen J, Gilijamse PW, Maas MA, Lewis MR, Nicholson JK, Verheij J, Heger M.

Biochim Biophys Acta. 2018 Mar;1864(3):942-951. doi: 10.1016/j.bbadis.2017.11.022. Epub 2017 Nov 28.


Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.

Gehrke N, Nagel M, Straub BK, Wörns MA, Schuchmann M, Galle PR, Schattenberg JM.

Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3):G319-G333. doi: 10.1152/ajpgi.00097.2017. Epub 2017 Nov 30.


An extract from the Atlantic brown algae Saccorhiza polyschides counteracts diet-induced obesity in mice via a gut related multi-factorial mechanisms.

Huebbe P, Nikolai S, Schloesser A, Herebian D, Campbell G, Glüer CC, Zeyner A, Demetrowitsch T, Schwarz K, Metges CC, Roeder T, Schultheiss G, Ipharraguerre IR, Rimbach G.

Oncotarget. 2017 May 23;8(43):73501-73515. doi: 10.18632/oncotarget.18113. eCollection 2017 Sep 26.


Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases.

Li Y, Tang R, Leung PSC, Gershwin ME, Ma X.

Autoimmun Rev. 2017 Sep;16(9):885-896. doi: 10.1016/j.autrev.2017.07.002. Epub 2017 Jul 8. Review.


Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats.

Yan J, Xie G, Liang C, Hu Y, Zhao A, Huang F, Hu P, Liu P, Jia W, Wang X.

Sci Rep. 2017 Jun 23;7(1):4211. doi: 10.1038/s41598-017-04536-5.


Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes.

Oizumi K, Sekine S, Fukagai M, Susukida T, Ito K.

J Pharm Sci. 2017 Sep;106(9):2412-2419. doi: 10.1016/j.xphs.2017.05.017. Epub 2017 May 26.


The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.

Cai SY, Boyer JL.

Dig Dis. 2017;35(3):232-234. doi: 10.1159/000450916. Epub 2017 Mar 1.


Mechanisms of Tauroursodeoxycholate-Mediated Hepatoprotection.

Häussinger D, Kordes C.

Dig Dis. 2017;35(3):224-231. doi: 10.1159/000450915. Epub 2017 Mar 1. Review.


The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.

Chang JC, Beuers U, Oude Elferink RP.

Dig Dis. 2017;35(3):217-223. doi: 10.1159/000450914. Epub 2017 Mar 1. Review.


Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L.

Cancer Cell. 2016 Dec 12;30(6):909-924. doi: 10.1016/j.ccell.2016.10.007. Epub 2016 Nov 23.


MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.

Hu X, Jogasuria A, Wang J, Kim C, Han Y, Shen H, Wu J, You M.

J Biol Chem. 2016 Oct 21;291(43):22482-22495. Epub 2016 Aug 29.

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