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Items: 1 to 20 of 334

1.

Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53.

Yan L, Chen Z, Wu L, Su Y, Wang X, Tang N.

Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.

PMID:
29908302
2.

A Transcriptional Regulatory Network Containing Nuclear Receptors and Long Noncoding RNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells.

Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, Zhong XB.

Mol Pharmacol. 2018 Jul;94(1):749-759. doi: 10.1124/mol.118.112235. Epub 2018 Apr 24.

PMID:
29691280
3.

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin.

Lutz JD, Kirby BJ, Wang L, Song Q, Ling J, Massetto B, Worth A, Kearney BP, Mathias A.

Clin Pharmacol Ther. 2018 Mar 23. doi: 10.1002/cpt.1073. [Epub ahead of print]

PMID:
29569723
4.

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine.

Lutz JD, Kirby BJ, Wang L, Song Q, Ling J, Massetto B, Worth A, Kearney BP, Mathias A.

Clin Pharmacol Ther. 2018 Mar 23. doi: 10.1002/cpt.1072. [Epub ahead of print]

PMID:
29569712
5.

[Transcriptional regulation effect of THSG and anthraquinones in tubers of Polygonum multiflorum based on human progesterone X receptor (PXR) mediated CYP3A4 rapid screening system].

Zhang ZY, Yang L, Huang XY, Wang MX, Ma ZC, Tang XL, Wang YG, Gao Y.

Zhongguo Zhong Yao Za Zhi. 2017 Dec;42(24):4827-4833. doi: 10.19540/j.cnki.cjcmm.20171010.006. Chinese.

PMID:
29493154
6.

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes.

Moscovitz JE, Kalgutkar AS, Nulick K, Johnson N, Lin Z, Goosen TC, Weng Y.

J Pharmacol Exp Ther. 2018 May;365(2):262-271. doi: 10.1124/jpet.117.247296. Epub 2018 Feb 12.

PMID:
29440451
7.

Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.

Taneja G, Chu C, Maturu P, Moorthy B, Ghose R.

Drug Metab Dispos. 2018 Apr;46(4):397-404. doi: 10.1124/dmd.117.079160. Epub 2018 Feb 12.

PMID:
29440179
8.

A human xenobiotic nuclear receptor contributes to nonresponsiveness of Mycobacterium tuberculosis to the antituberculosis drug rifampicin.

Bhagyaraj E, Tiwari D, Ahuja N, Nanduri R, Saini A, Kalra R, Kumar S, Janmeja AK, Gupta P.

J Biol Chem. 2018 Mar 9;293(10):3747-3757. doi: 10.1074/jbc.M117.818377. Epub 2018 Jan 22.

PMID:
29358328
9.

Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.

Ogasawara A, Kato N, Torimoto N, Aohara F, Ohashi R, Yamada Y, Taniguchi H.

Drug Metab Lett. 2018 Jan 18. doi: 10.2174/1872312812666180119114013. [Epub ahead of print]

PMID:
29357810
10.

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windsh├╝gel B.

Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22.

PMID:
29356861
11.

Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.

Chang HY, Chen CJ, Ma WC, Cheng WK, Lin YN, Lee YR, Chen JJ, Lim YP.

Phytomedicine. 2017 Dec 1;36:37-49. doi: 10.1016/j.phymed.2017.09.016. Epub 2017 Sep 25.

PMID:
29157826
12.

Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice.

Yamasaki Y, Kobayashi K, Inaba A, Uehara D, Tojima H, Kakizaki S, Chiba K.

Xenobiotica. 2017 Nov 23:1-8. doi: 10.1080/00498254.2017.1400128. [Epub ahead of print]

PMID:
29095659
13.

Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity.

Lin YN, Chen CJ, Chang HY, Cheng WK, Lee YR, Chen JJ, Lim YP.

J Agric Food Chem. 2017 Oct 4;65(39):8606-8616. doi: 10.1021/acs.jafc.7b02696. Epub 2017 Sep 25.

PMID:
28945086
14.

Intracellular localization of pregnane X receptor in HepG2 cells cultured by the hanging drop method.

Yokobori K, Kobayashi K, Azuma I, Akita H, Chiba K.

Drug Metab Pharmacokinet. 2017 Oct;32(5):265-272. doi: 10.1016/j.dmpk.2017.08.001. Epub 2017 Aug 26.

PMID:
28942083
15.

Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.

Moscovitz JE, Lin Z, Johnson N, Tu M, Goosen TC, Weng Y, Kalgutkar AS.

Xenobiotica. 2018 Jul;48(7):647-655. doi: 10.1080/00498254.2017.1353163. Epub 2017 Jul 24.

PMID:
28685622
16.

Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential.

Arakawa H, Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T.

Biol Pharm Bull. 2017;40(7):967-974. doi: 10.1248/bpb.b16-00885.

17.

Role of vitamin D pathway gene polymorphisms on rifampicin plasma and intracellular pharmacokinetics.

Allegra S, Fatiguso G, Calcagno A, Baietto L, Motta I, Favata F, Cusato J, Bonora S, Di Perri G, D'Avolio A.

Pharmacogenomics. 2017 Jun;18(9):865-880. doi: 10.2217/pgs-2017-0176. Epub 2017 Jun 8.

PMID:
28594304
18.

miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3.

Rao ZZ, Zhang XW, Ding YL, Yang MY.

PLoS One. 2017 Jun 2;12(6):e0178702. doi: 10.1371/journal.pone.0178702. eCollection 2017.

19.

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.

Rasmussen MK, Daujat-Chavanieu M, Gerbal-Chaloin S.

Toxicol Lett. 2017 Aug 5;277:1-8. doi: 10.1016/j.toxlet.2017.05.029. Epub 2017 May 29.

PMID:
28571685
20.

Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNF╬▒ in Vascular Endothelial Cells through a PXR-Dependent Mechanism.

Wang S, Xie X, Lei T, Zhang K, Lai B, Zhang Z, Guan Y, Mao G, Xiao L, Wang N.

Mol Pharmacol. 2017 Sep;92(3):256-264. doi: 10.1124/mol.116.108100. Epub 2017 May 25.

PMID:
28546421

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