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9-cis-retinoic acid elevates MRP3 expression by inhibiting sumoylation of RXRα to alleviate cholestatic liver injury.

Yuan Z, Wang G, Qu J, Wang X, Li K.

Biochem Biophys Res Commun. 2018 Jun 15. pii: S0006-291X(18)31301-9. doi: 10.1016/j.bbrc.2018.06.001. [Epub ahead of print]


Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium.

Liu H, Zhan S, Zhang Y, Ma Y, Chen L, Chen L, Dong H, Ma M, Zhang Z.

BMC Complement Altern Med. 2017 Nov 16;17(1):491. doi: 10.1186/s12906-017-1997-4.


On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness.

Jenniskens M, Güiza F, Oorts M, Vander Perre S, Derde S, Dufour T, Thiessen S, Annaert P, Van den Berghe G, Langouche L.

Shock. 2018 Aug;50(2):187-198. doi: 10.1097/SHK.0000000000001001.


Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes.

Boucher JG, Gagné R, Rowan-Carroll A, Boudreau A, Yauk CL, Atlas E.

PLoS One. 2016 Sep 29;11(9):e0163318. doi: 10.1371/journal.pone.0163318. eCollection 2016.


Role of farnesoid X receptor and bile acids in alcoholic liver disease.

Manley S, Ding W.

Acta Pharm Sin B. 2015 Mar;5(2):158-67. doi: 10.1016/j.apsb.2014.12.011. Epub 2015 Mar 9. Review.


New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.

Beuers U, Trauner M, Jansen P, Poupon R.

J Hepatol. 2015 Apr;62(1 Suppl):S25-37. doi: 10.1016/j.jhep.2015.02.023. Review.


Deficiency of Capicua disrupts bile acid homeostasis.

Kim E, Park S, Choi N, Lee J, Yoe J, Kim S, Jung HY, Kim KT, Kang H, Fryer JD, Zoghbi HY, Hwang D, Lee Y.

Sci Rep. 2015 Feb 5;5:8272. doi: 10.1038/srep08272.


Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.

Koutsounas I, Theocharis S, Delladetsima I, Patsouris E, Giaginis C.

Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):523-32. doi: 10.1517/17425255.2014.999664. Epub 2015 Jan 2. Review.


Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease.

Wu W, Zhu B, Peng X, Zhou M, Jia D, Gu J.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):68-73. doi: 10.1016/j.bbrc.2013.11.057. Epub 2013 Nov 20.


A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression.

Xu S, Sun AQ, Suchy FJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. doi: 10.1152/ajpgi.00138.2013. Epub 2013 Nov 21.


Impaired bile acid handling and aggravated liver injury in mice expressing a hepatocyte-specific RXRα variant lacking the DNA-binding domain.

Kosters A, Felix JC, Desai MS, Karpen SJ.

J Hepatol. 2014 Feb;60(2):362-9. doi: 10.1016/j.jhep.2013.09.026. Epub 2013 Oct 10.


Impact of parenteral nutrition versus fasting on hepatic bile acid production and transport in a rabbit model of prolonged critical illness.

Vanwijngaerden YM, Langouche L, Derde S, Liddle C, Coulter S, van den Berghe G, Mesotten D.

Shock. 2014 Jan;41(1):48-54. doi: 10.1097/SHK.0000000000000046.


SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes.

Balasubramaniyan N, Luo Y, Sun AQ, Suchy FJ.

J Biol Chem. 2013 May 10;288(19):13850-62. doi: 10.1074/jbc.M112.443937. Epub 2013 Apr 1.


FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver.

Rosales R, Romero MR, Vaquero J, Monte MJ, Requena P, Martinez-Augustin O, Sanchez de Medina F, Marin JJ.

Biochem Pharmacol. 2013 Mar 15;85(6):829-38. doi: 10.1016/j.bcp.2013.01.001. Epub 2013 Jan 10.


Gene-specific alterations of hepatic gene expression by ligand activation or hepatocyte-selective inhibition of retinoid X receptor-α signalling during inflammation.

Kosters A, Tian F, Wan YJ, Karpen SJ.

Liver Int. 2012 Feb;32(2):321-30. doi: 10.1111/j.1478-3231.2011.02664.x. Epub 2011 Nov 1. Erratum in: Liver Int. 2013 Apr;33(4):652. Wan, Yvonne Yu-Jie [corrected to Wan, Yu-Jui Yvonne].


Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression.

Vanwijngaerden YM, Wauters J, Langouche L, Vander Perre S, Liddle C, Coulter S, Vanderborght S, Roskams T, Wilmer A, Van den Berghe G, Mesotten D.

Hepatology. 2011 Nov;54(5):1741-52. doi: 10.1002/hep.24582.


Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis.

Chai J, Luo D, Wu X, Wang H, He Y, Li Q, Zhang Y, Chen L, Peng ZH, Xiao T, Wang R, Chen W.

J Gastrointest Surg. 2011 Jun;15(6):996-1004. doi: 10.1007/s11605-011-1473-2. Epub 2011 Feb 26.


Vitamin A deficiency associated with enhanced proliferation of bile duct epithelial cells in the rat.

Weiss B, Barshack I, Onaca N, Goldberg I, Berkovich Z, Melzer E, Jonas A, Reifen R.

Isr Med Assoc J. 2010 Feb;12(2):82-6.


Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis.

Wagner M, Zollner G, Trauner M.

Semin Liver Dis. 2010 May;30(2):160-77. doi: 10.1055/s-0030-1253225. Epub 2010 Apr 26. Review.


Deciphering the nuclear bile acid receptor FXR paradigm.

Modica S, Gadaleta RM, Moschetta A.

Nucl Recept Signal. 2010 Nov 19;8:e005. doi: 10.1621/nrs.08005. Review.

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