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Items: 1 to 20 of 543

1.

Increased interleukin-23 receptor (IL-23R) expression is associated with disease severity in acute-on-chronic liver failure.

Khanam A, Trehanpati N, Sarin SK.

Liver Int. 2018 Dec 2. doi: 10.1111/liv.14015. [Epub ahead of print]

PMID:
30506912
2.

A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders.

Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidi-Niaragh F, Yazdani R, Bautista JM, Azizi G.

Mol Immunol. 2019 Jan;105:107-115. doi: 10.1016/j.molimm.2018.11.015. Epub 2018 Nov 28.

PMID:
30502718
3.

Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction.

Noguchi M, Nomura A, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Maeda K, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Crowe P, Tao H, Thacher S, Adachi T.

Sci Rep. 2018 Nov 26;8(1):17374. doi: 10.1038/s41598-018-35783-9.

4.

The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review.

Cafferata EA, Jerez A, Vernal R, Monasterio G, Pandis N, Faggion CM Jr.

J Periodontal Res. 2018 Nov 25. doi: 10.1111/jre.12629. [Epub ahead of print] Review.

PMID:
30474205
5.

Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis.

Singh AM, Sherenian MG, Kim KY, Erickson KA, Yang A, Mestan K, Ernst LM, Kumar R.

Allergy Asthma Clin Immunol. 2018 Nov 19;14:66. doi: 10.1186/s13223-018-0297-y. eCollection 2018.

6.

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients.

Bassolas-Molina H, Raymond E, Labadia M, Wahle J, Ferrer-Picón E, Panzenbeck M, Zheng J, Harcken C, Hughes R, Turner M, Smith D, Calderón-Gómez E, Esteller M, Carrasco A, Esteve M, Dotti I, Corraliza AM, Masamunt MC, Arajol C, Guardiola J, Ricart E, Nabozny G, Salas A.

Front Immunol. 2018 Oct 22;9:2307. doi: 10.3389/fimmu.2018.02307. eCollection 2018.

7.

Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization.

Tamehiro N, Nishida K, Sugita Y, Hayakawa K, Oda H, Nitta T, Nakano M, Nishioka A, Yanobu-Takanashi R, Goto M, Okamura T, Adachi R, Kondo K, Morita A, Suzuki H.

J Allergy Clin Immunol. 2018 Oct 17. pii: S0091-6749(18)31444-1. doi: 10.1016/j.jaci.2018.09.032. [Epub ahead of print]

PMID:
30339851
8.

Disturbed Th17/Treg balance, cytokines, and miRNAs in peripheral blood of patients with Behcet's disease.

Ahmadi M, Yousefi M, Abbaspour-Aghdam S, Dolati S, Aghebati-Maleki L, Eghbal-Fard S, Khabbazi A, Rostamzadeh D, Alipour S, Shabani M, Nouri M, Babaloo Z.

J Cell Physiol. 2019 Apr;234(4):3985-3994. doi: 10.1002/jcp.27207. Epub 2018 Oct 14.

PMID:
30317557
9.

Decreased RORC expression and downstream signaling in HTLV-1-associated adult T-cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

Subramanian K, Dierckx T, Khouri R, Menezes SM, Kagdi H, Taylor GP, Farre L, Bittencourt A, Kataoka K, Ogawa S, Van Weyenbergh J.

Int J Cancer. 2018 Oct 10. doi: 10.1002/ijc.31922. [Epub ahead of print]

PMID:
30303535
10.

Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003.

Sasaki Y, Odan M, Yamamoto S, Kida S, Ueyama A, Shimizu M, Haruna T, Watanabe A, Okuno T.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553. doi: 10.1016/j.bmcl.2018.09.032. Epub 2018 Sep 27.

PMID:
30301676
11.

The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia.

Eghbal-Fard S, Yousefi M, Heydarlou H, Ahmadi M, Taghavi S, Movasaghpour A, Jadidi-Niaragh F, Yousefi B, Dolati S, Hojjat-Farsangi M, Rikhtegar R, Nouri M, Aghebati-Maleki L.

J Cell Physiol. 2019 Apr;234(4):5106-5116. doi: 10.1002/jcp.27315. Epub 2018 Oct 2.

PMID:
30277561
12.

The changes of expressive levels of IL-17A, STAT3, and RORγt in different invasive pulmonary aspergillosis mice.

Xu LN, Xu RA, Zhang D, Su SS, Xu HY, Wu Q, Li YP.

Infect Drug Resist. 2018 Aug 27;11:1321-1328. doi: 10.2147/IDR.S172949. eCollection 2018.

13.

The role of RORα in salivary gland lesions in patients with primary Sjögren's syndrome.

Weng X, Liu Y, Cui S, Cheng B.

Arthritis Res Ther. 2018 Sep 6;20(1):205. doi: 10.1186/s13075-018-1698-5.

14.

Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.

Jia H, Sodhi CP, Yamaguchi Y, Lu P, Ladd MR, Werts A, Fulton WB, Wang S, Prindle T Jr, Hackam DJ.

Shock. 2018 Aug 24. doi: 10.1097/SHK.0000000000001255. [Epub ahead of print]

PMID:
30148762
15.

Interleukin-17-producing γδ T (γδ17) cells in inflammatory diseases.

Akitsu A, Iwakura Y.

Immunology. 2018 Dec;155(4):418-426. doi: 10.1111/imm.12993. Epub 2018 Sep 10. Review.

16.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G.

J Med Chem. 2018 Sep 9. doi: 10.1021/acs.jmedchem.8b00392. [Epub ahead of print]

PMID:
30130103
17.

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model.

Igaki K, Nakamura Y, Komoike Y, Uga K, Shibata A, Ishimura Y, Yamasaki M, Tsukimi Y, Tsuchimori N.

Inflammation. 2018 Aug 18. doi: 10.1007/s10753-018-0875-7. [Epub ahead of print]

PMID:
30121880
18.

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Narjes F, Xue Y, von Berg S, Malmberg J, Llinas A, Olsson RI, Jirholt J, Grindebacke H, Leffler A, Hossain N, Lepistö M, Thunberg L, Leek H, Aagaard A, McPheat J, Hansson EL, Bäck E, Tångefjord S, Chen R, Xiong Y, Hongbin G, Hansson TG.

J Med Chem. 2018 Sep 13;61(17):7796-7813. doi: 10.1021/acs.jmedchem.8b00783. Epub 2018 Aug 27.

PMID:
30095900
19.

Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening.

Rauhamäki S, Postila PA, Lätti S, Niinivehmas S, Multamäki E, Liedl KR, Pentikäinen OT.

ACS Omega. 2018 Jun 30;3(6):6259-6266. doi: 10.1021/acsomega.8b00603. Epub 2018 Jun 11.

20.

p300 promotes differentiation of Th17 cells via positive regulation of the nuclear transcription factor RORγt in acute respiratory distress syndrome.

Chen Y, Wang D, Zhao Y, Huang B, Cao H, Qi D.

Immunol Lett. 2018 Oct;202:8-15. doi: 10.1016/j.imlet.2018.07.004. Epub 2018 Jul 29.

PMID:
30009847

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