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Items: 1 to 20 of 2420

1.

Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.

Šarenac TM, Mikov M.

Front Pharmacol. 2018 Sep 25;9:939. doi: 10.3389/fphar.2018.00939. eCollection 2018. Review.

2.

Effects of carbamazepine on the P-gp and CYP3A expression correlated with PXR or NF-κB activity in the bEnd.3 cells.

Ke XJ, Cheng YF, Yu N, Di Q.

Neurosci Lett. 2018 Oct 9;690:48-55. doi: 10.1016/j.neulet.2018.10.016. [Epub ahead of print]

PMID:
30312753
3.

Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-stimulated HepG2 Cells.

Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.

J Histochem Cytochem. 2018 Oct 10:22155418804507. doi: 10.1369/0022155418804507. [Epub ahead of print]

PMID:
30303767
4.

Human PXR-mediated transcriptional activation of CYP3A4 by "Fuzi" extracts.

Huang G, Yang L, Zhang Z, Ren S, Tang X, Zhou W, Wang Y, Ma Z, Gao S, Gao Y.

Toxicol Mech Methods. 2018 Oct 10:1-19. doi: 10.1080/15376516.2018.1534296. [Epub ahead of print]

PMID:
30303438
5.

Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand.

Knebel C, Kebben J, Eberini I, Palazzolo L, Hammer HS, Süssmuth RD, Heise T, Hessel-Pras S, Lampen A, Braeuning A, Marx-Stoelting P.

Arch Toxicol. 2018 Oct 6. doi: 10.1007/s00204-018-2321-x. [Epub ahead of print]

PMID:
30293151
6.

Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells.

Lee HJ, Pyo MC, Shin HS, Ryu D, Lee KW.

Food Chem Toxicol. 2018 Oct 3;122:59-68. doi: 10.1016/j.fct.2018.10.004. [Epub ahead of print]

PMID:
30291945
7.

Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease.

Elbel EE, Lavine JE, Downes M, Van Natta M, Yu R, Schwimmer JB, Behling C, Brunt EM, Tonascia J, Evans R.

Hepatol Commun. 2018 Sep 27;2(10):1213-1226. doi: 10.1002/hep4.1232. eCollection 2018 Oct.

8.

Toxicity assessment of groundwater contaminated by petroleum hydrocarbons at a well-characterized, aged, crude oil release site.

McGuire JT, Cozzarelli IM, Bekins B, Link H, Martinovic-Weigelt D.

Environ Sci Technol. 2018 Oct 1. doi: 10.1021/acs.est.8b03657. [Epub ahead of print]

PMID:
30272965
9.

MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor.

Li J, Zhao J, Wang H, Li X, Liu A, Qin Q, Li B.

Onco Targets Ther. 2018 Sep 17;11:5885-5894. doi: 10.2147/OTT.S179509. eCollection 2018.

10.

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Ghosh C, Hossain M, Mishra S, Khan S, Gonzalez-Martinez J, Marchi N, Janigro D, Bingaman W, Najm I.

Epilepsia. 2018 Sep 28. doi: 10.1111/epi.14567. [Epub ahead of print]

PMID:
30264400
11.

Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation.

Gabbia D, Pozzo L, Zigiotto G, Roverso M, Sacchi D, Dalla Pozza A, Carrara M, Bogialli S, Floreani A, Guido M, De Martin S.

PLoS One. 2018 Sep 25;13(9):e0204336. doi: 10.1371/journal.pone.0204336. eCollection 2018.

12.

Identification of Modulators that Activate the Constitutive Androstane Receptor from the Tox21 10K Compound Library.

Lynch C, Mackowiak B, Huang R, Li L, Heyward S, Sakamuru S, Wang H, Xia M.

Toxicol Sci. 2018 Sep 22. doi: 10.1093/toxsci/kfy242. [Epub ahead of print]

PMID:
30247703
13.

Effects of simvastatin on the PXR signaling pathway and the liver histology in Mugilogobius abei.

Wang C, Ku P, Nie X, Bao S, Wang Z, Li K.

Sci Total Environ. 2018 Sep 11;651(Pt 1):399-409. doi: 10.1016/j.scitotenv.2018.09.133. [Epub ahead of print]

PMID:
30240922
14.

The role of xenobiotic receptors on hepatic glycolipid metabolism.

Chen K, Zhong J, Hu L, Li R, Duc Q, Cai J, Li Y, Gao Y, Cui X, Yang X, Wu X, Yao L, Dai J, Wang Y, Jin H.

Curr Drug Metab. 2018 Sep 18. doi: 10.2174/1389200219666180918152241. [Epub ahead of print]

PMID:
30227815
15.

Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.

Takeuchi Y, Kito A, Itoh S, Naruse H, Fujikawa J, Sadek KM, Akiyama S, Yamashiro T, Wakisaka S, Abe M.

Exp Cell Res. 2018 Oct 15;371(2):417-425. doi: 10.1016/j.yexcr.2018.09.002. Epub 2018 Sep 5.

PMID:
30193838
16.

Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

Pollet M, Krutmann J, Haarmann-Stemmann T.

Front Pharmacol. 2018 Aug 20;9:935. doi: 10.3389/fphar.2018.00935. eCollection 2018. No abstract available.

17.

Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4.

He Y, Zhou X, Li X, Jin X, Wang X, Pan X, Bi D.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Dec;214:9-16. doi: 10.1016/j.cbpc.2018.08.006. Epub 2018 Aug 25.

PMID:
30153482
18.

Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators.

Vaz RJ, Li Y, Chellaraj V, Reiling S, Kuntzweiler T, Yang D, Shen H, Batchelor JD, Zhang Y, Chen X, McLean LR, Kosley R Jr.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3194-3196. doi: 10.1016/j.bmcl.2018.08.022. Epub 2018 Aug 20.

PMID:
30146095
19.

Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries.

Zhang M, Zhang Z, Xie X, Yao Q, Liu J, Lai B, Xiao L, Wang N.

J Cell Physiol. 2018 Aug 21. doi: 10.1002/jcp.27215. [Epub ahead of print]

PMID:
30132884
20.

Clinical Significance of Organic Anion Transporting Polypeptide Gene Expression in High-Grade Serous Ovarian Cancer.

Svoboda M, Mungenast F, Gleiss A, Vergote I, Vanderstichele A, Sehouli J, Braicu E, Mahner S, Jäger W, Mechtcheriakova D, Cacsire-Tong D, Zeillinger R, Thalhammer T, Pils D.

Front Pharmacol. 2018 Aug 7;9:842. doi: 10.3389/fphar.2018.00842. eCollection 2018.

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