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Items: 1 to 20 of 1277

1.

In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.

Niu B, Coslo DM, Bataille AR, Albert I, Pugh BF, Omiecinski CJ.

Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky692. [Epub ahead of print]

PMID:
30102401
2.

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.

Klag T, Thomas M, Ehmann D, Courth L, Mailänder-Sanchez D, Weiss TS, Dayoub R, Abshagen K, Vollmar B, Thasler WE, Stange EF, Berg CP, Malek NP, Zanger UM, Wehkamp J.

Front Immunol. 2018 Jul 27;9:1735. doi: 10.3389/fimmu.2018.01735. eCollection 2018.

3.

Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis.

Kajta M, Wnuk A, Rzemieniec J, Lason W, Mackowiak M, Chwastek E, Staniszewska M, Nehring I, Wojtowicz AK.

Mol Neurobiol. 2018 Aug 10. doi: 10.1007/s12035-018-1285-4. [Epub ahead of print]

PMID:
30097849
4.

Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators.

Lake BG.

Toxicol Res (Camb). 2018 Mar 12;7(4):697-717. doi: 10.1039/c8tx00008e. eCollection 2018 Jul 1. Review.

PMID:
30090615
5.

Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action.

Yamada T.

Toxicol Res (Camb). 2018 Jan 16;7(4):681-696. doi: 10.1039/c7tx00288b. eCollection 2018 Jul 1. Review.

PMID:
30090614
6.

Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice.

Ohara A, Takahashi Y, Kondo M, Okuda Y, Takeda S, Kushida M, Kobayashi K, Sumida K, Yamada T.

Toxicol Res (Camb). 2017 Aug 24;6(6):795-813. doi: 10.1039/c7tx00163k. eCollection 2017 Nov 1.

PMID:
30090543
7.

Effect of amyloid beta on ATP-binding cassette transporter expression and activity in porcine brain microvascular endothelial cells.

Shubbar MH, Penny JI.

Biochim Biophys Acta. 2018 Jul 23;1862(10):2314-2322. doi: 10.1016/j.bbagen.2018.07.021. [Epub ahead of print]

PMID:
30048740
8.

Effects and Mechanism of Nano-Copper Exposure on Hepatic Cytochrome P450 Enzymes in Rats.

Tang H, Xu M, Shi F, Ye G, Lv C, Luo J, Zhao L, Li Y.

Int J Mol Sci. 2018 Jul 23;19(7). pii: E2140. doi: 10.3390/ijms19072140.

9.

Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge CM, Clark BJ, Prough RA.

Vitam Horm. 2018;108:1-28. doi: 10.1016/bs.vh.2018.02.002. Epub 2018 Mar 16.

PMID:
30029723
10.

AhR signaling pathways and regulatory functions.

Larigot L, Juricek L, Dairou J, Coumoul X.

Biochim Open. 2018 Jun 11;7:1-9. doi: 10.1016/j.biopen.2018.05.001. eCollection 2018 Dec. Review.

11.

Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics.

Kawase A, Tateishi S, Kazaoka A.

Biopharm Drug Dispos. 2018 Jun;39(6):308-314. doi: 10.1002/bdd.2147.

PMID:
29959875
12.

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor.

Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A, Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L.

Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877. eCollection 2018 Jun.

13.

Role of YAP activation in nuclear receptor CAR-mediated proliferation of mouse hepatocytes.

Abe T, Amaike Y, Shizu R, Takahashi M, Kano M, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Yoshinari K.

Toxicol Sci. 2018 Jun 8. doi: 10.1093/toxsci/kfy149. [Epub ahead of print]

PMID:
29893953
14.

CAR-mediated repression of Cdkn1a(p21) is accompanied by the Akt activation.

Yarushkin AA, Mazin ME, Yunusova AY, Korchagina KV, Pustylnyak YA, Prokopyeva EA, Pustylnyak VO.

Biochem Biophys Res Commun. 2018 Jun 11. pii: S0006-291X(18)31344-5. doi: 10.1016/j.bbrc.2018.06.032. [Epub ahead of print]

PMID:
29890134
15.

TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling.

Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK.

Hepatology. 2018 Jun 11. doi: 10.1002/hep.30109. [Epub ahead of print]

PMID:
29888801
16.

The Therapeutic Role of Xenobiotic Nuclear Receptors against Metabolic Syndrome.

Pu S, Wu X, Yang X, Zhang Y, Dai Y, Zhang Y, Wu X, Liu Y, Cui X, Jin H, Cao J, Li R, Cai J, Cao Q, Hu L, Gao Y.

Curr Drug Metab. 2018 Jun 10. doi: 10.2174/1389200219666180611083155. [Epub ahead of print]

PMID:
29886826
17.

Regulation of Cytosolic Sulfotransferases in Models of Human Hepatocyte Development.

Dubaisi S, Barrett KG, Fang H, Guzman-Lepe J, Soto-Gutierrez A, Kocarek TA, Runge-Morris M.

Drug Metab Dispos. 2018 Aug;46(8):1146-1156. doi: 10.1124/dmd.118.081398. Epub 2018 Jun 1.

PMID:
29858374
18.

Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction.

Nagai M, Hosaka T, Satsukawa M, Yoshinari K.

J Pharm Sci. 2018 Sep;107(9):2479-2488. doi: 10.1016/j.xphs.2018.05.008. Epub 2018 May 23.

PMID:
29802934
19.

The Roles of Xenobiotic Receptors: Beyond Chemical Disposition.

Mackowiak B, Hodge J, Stern S, Wang H.

Drug Metab Dispos. 2018 Sep;46(9):1361-1371. doi: 10.1124/dmd.118.081042. Epub 2018 May 14.

PMID:
29759961
20.

A current structural perspective on PXR and CAR in drug metabolism.

Buchman CD, Chai SC, Chen T.

Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):635-647. doi: 10.1080/17425255.2018.1476488. Epub 2018 May 30. Review.

PMID:
29757018

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