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Items: 1 to 20 of 195

1.

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences.

Molusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1493-1503. doi: 10.1161/ATVBAHA.118.311212. Epub 2018 May 31.

PMID:
29853564
2.

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.

Tedesco D, Thapa M, Chin CY, Ge Y, Gong M, Li J, Gumber S, Speck P, Elrod EJ, Burd EM, Kitchens WH, Magliocca JF, Adams AB, Weiss DS, Mohamadzadeh M, Grakoui A.

Gastroenterology. 2018 Jun;154(8):2178-2193. doi: 10.1053/j.gastro.2018.02.019. Epub 2018 Feb 15.

PMID:
29454797
3.

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule.

Meyer K, Ostrenko O, Bourantas G, Morales-Navarrete H, Porat-Shliom N, Segovia-Miranda F, Nonaka H, Ghaemi A, Verbavatz JM, Brusch L, Sbalzarini I, Kalaidzidis Y, Weigert R, Zerial M.

Cell Syst. 2017 Mar 22;4(3):277-290.e9. doi: 10.1016/j.cels.2017.02.008. Epub 2017 Mar 18.

4.

Upregulation of PDZK1 by Calculus Bovis Sativus May Play an Important Role in Restoring Biliary Transport Function in Intrahepatic Cholestasis.

Xiang D, Wu T, Feng CY, Li XP, Xu YJ, He WX, Lei K, Cai HJ, Zhang CL, Liu D.

Evid Based Complement Alternat Med. 2017;2017:1640187. doi: 10.1155/2017/1640187. Epub 2017 Jan 4.

5.
6.

Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease.

Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J.

Obes Surg. 2017 May;27(5):1284-1291. doi: 10.1007/s11695-016-2446-z.

PMID:
27812789
7.

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.

Dragovic S, Vermeulen NP, Gerets HH, Hewitt PG, Ingelman-Sundberg M, Park BK, Juhila S, Snoeys J, Weaver RJ.

Arch Toxicol. 2016 Dec;90(12):2979-3003. Epub 2016 Sep 22. Review.

8.

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition.

Deharde D, Schneider C, Hiller T, Fischer N, Kegel V, Lübberstedt M, Freyer N, Hengstler JG, Andersson TB, Seehofer D, Pratschke J, Zeilinger K, Damm G.

Arch Toxicol. 2016 Oct;90(10):2497-511. doi: 10.1007/s00204-016-1758-z. Epub 2016 Jun 21.

PMID:
27325308
9.

Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo.

Niu X, de Graaf IA, van de Vegte D, Langelaar-Makkinje M, Sekine S, Groothuis GM.

Toxicol In Vitro. 2015 Feb;29(1):168-75.

PMID:
25450747
10.

Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.

Xu D, Wu M, Nishimura S, Nishimura T, Michie SA, Zheng M, Yang Z, Yates AJ, Day JS, Hillgren KM, Takeda ST, Guan Y, Guo Y, Peltz G.

J Pharmacol Exp Ther. 2015 Feb;352(2):274-80. doi: 10.1124/jpet.114.220798. Epub 2014 Nov 25.

11.

Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment.

Germano D, Uteng M, Pognan F, Chibout SD, Wolf A.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):79-94. doi: 10.1016/j.tiv.2014.05.009. Epub 2014 Jun 14.

12.

Mechanism-based pharmacokinetic modeling to evaluate transporter-enzyme interplay in drug interactions and pharmacogenetics of glyburide.

Varma MV, Scialis RJ, Lin J, Bi YA, Rotter CJ, Goosen TC, Yang X.

AAPS J. 2014 Jul;16(4):736-48. doi: 10.1208/s12248-014-9614-7. Epub 2014 May 17.

13.

The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects.

Deetman PE, Bakker SJ, Kwakernaak AJ, Navis G, Dullaart RP; PREVEND Study Group.

PLoS One. 2014 Mar 3;9(3):e90886. doi: 10.1371/journal.pone.0090886. eCollection 2014.

15.

An assessment of the intestinal lumen as a site for intervention in reducing body burdens of organochlorine compounds.

Jandacek RJ, Genuis SJ.

ScientificWorldJournal. 2013;2013:205621. doi: 10.1155/2013/205621. Epub 2013 Feb 7. Review.

16.

Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats.

Xu R, Zhang X, Yang J, Liu X, Davey AK, Wang J.

Biopharm Drug Dispos. 2012 Jul;33(5):235-45. doi: 10.1002/bdd.1789. Epub 2012 May 21.

PMID:
22508486
17.

Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network.

Schaub M, Nussbaum J, Verkade H, Ober EA, Stainier DY, Sakaguchi TF.

Dev Biol. 2012 Mar 1;363(1):128-37. doi: 10.1016/j.ydbio.2011.12.025. Epub 2011 Dec 23.

18.

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS.

Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.

19.

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.

Mongan MA, Dunn RT, Vonderfecht S, Everds N, Chen G, Su C, Higgins-Garn M, Chen Y, Afshari CA, Williamson TL, Carlock L, Dipalma C, Moss S, Bussiere J, Qualls C, He YD, Hamadeh HK.

PLoS One. 2010 Dec 21;5(12):e15595. doi: 10.1371/journal.pone.0015595.

20.

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