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Items: 1 to 20 of 503

1.

Distribution of bile acid receptor TGR5 in the gastrointestinal tract of dogs.

Giaretta PR, Suchodolski JS, Blick AK, Steiner JM, Lidbury JA, Rech RR.

Histol Histopathol. 2018 Jul 12:18025. doi: 10.14670/HH-18-025. [Epub ahead of print]

PMID:
29999170
2.

Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation.

Miyazaki-Anzai S, Masuda M, Kohno S, Levi M, Shiozaki Y, Keenan AL, Miyazaki M.

J Lipid Res. 2018 Jul 5. pii: jlr.M087239. doi: 10.1194/jlr.M087239. [Epub ahead of print]

3.

Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice.

Dumas SN, Ntambi JM.

PLoS One. 2018 Jul 2;13(7):e0199682. doi: 10.1371/journal.pone.0199682. eCollection 2018.

4.

INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function.

Comeglio P, Cellai I, Mello T, Filippi S, Maneschi E, Corcetto F, Corno C, Sarchielli E, Morelli A, Rapizzi E, Bani D, Guasti D, Vannelli GB, Galli A, Adorini L, Maggi M, Vignozzi L.

J Endocrinol. 2018 Aug;238(2):107-127. doi: 10.1530/JOE-17-0557.

5.

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy.

Patel A, Yusta B, Matthews D, Charron MJ, Seeley RJ, Drucker DJ.

Mol Metab. 2018 Jun 9. pii: S2212-8778(18)30505-2. doi: 10.1016/j.molmet.2018.06.006. [Epub ahead of print]

6.

Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.

Wu X, Lv YG, Du YF, Chen F, Reed MN, Hu M, Suppiramaniam V, Tang SS, Hong H.

Brain Behav Immun. 2018 Jun 20. pii: S0889-1591(18)30234-4. doi: 10.1016/j.bbi.2018.06.018. [Epub ahead of print]

PMID:
29935310
7.

Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex.

Rizzetto L, Fava F, Tuohy KM, Selmi C.

J Autoimmun. 2018 May 31. pii: S0896-8411(18)30190-2. doi: 10.1016/j.jaut.2018.05.008. [Epub ahead of print] Review.

PMID:
29861127
8.

Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass.

Zhai H, Li Z, Peng M, Huang Z, Qin T, Chen L, Li H, Zhang H, Zhang W, Xu G.

EBioMedicine. 2018 Jun;32:201-214. doi: 10.1016/j.ebiom.2018.05.026. Epub 2018 May 30.

9.

INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis.

Li B, Yang N, Li C, Li C, Gao K, Xie X, Dong X, Yang J, Yang Q, Tong Z, Lu G, Li W.

Biochem Biophys Res Commun. 2018 Jun 7. pii: S0006-291X(18)31183-5. doi: 10.1016/j.bbrc.2018.05.120. [Epub ahead of print]

PMID:
29859191
10.

Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models.

Jena PK, Sheng L, Nagar N, Wu C, Barile D, Mills DA, Wan YY.

J Nutr Biochem. 2018 Jul;57:246-254. doi: 10.1016/j.jnutbio.2018.04.007. Epub 2018 Apr 25.

PMID:
29800811
11.

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice.

Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R.

J Biol Chem. 2018 Jun 29;293(26):10322-10332. doi: 10.1074/jbc.RA118.002733. Epub 2018 May 17.

PMID:
29773650
12.

Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice.

Hao Z, Leigh Townsend R, Mumphrey MB, Gettys TW, Yu S, Münzberg H, Morrison CD, Berthoud HR.

Obes Surg. 2018 May 16. doi: 10.1007/s11695-018-3297-6. [Epub ahead of print]

PMID:
29770924
13.

Potential use of bitter melon (Momordica charantia) derived compounds as antidiabetics: In silico and in vivo studies.

Elekofehinti OO, Ariyo EO, Akinjiyan MO, Olayeriju OS, Lawal AO, Adanlawo IG, Rocha JBT.

Pathophysiology. 2018 May 12. pii: S0928-4680(18)30058-0. doi: 10.1016/j.pathophys.2018.05.003. [Epub ahead of print]

PMID:
29764719
14.

Novel and emerging therapies for cholestatic liver diseases.

Goldstein J, Levy C.

Liver Int. 2018 May 14. doi: 10.1111/liv.13880. [Epub ahead of print] Review.

PMID:
29758112
15.

Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5.

Ibrahim E, Diakonov I, Arunthavarajah D, Swift T, Goodwin M, McIlvride S, Nikolova V, Williamson C, Gorelik J.

Sci Rep. 2018 May 8;8(1):7110. doi: 10.1038/s41598-018-25569-4.

16.

Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial.

Oduyebo I, Camilleri M, Nelson AD, Khemani D, Nord SL, Busciglio I, Burton D, Rhoten D, Ryks M, Carlson P, Donato L, Lueke A, Kim K, Rossi SJ, Zinsmeister AR.

Am J Gastroenterol. 2018 May;113(5):725-734. doi: 10.1038/s41395-018-0042-7. Epub 2018 May 2.

PMID:
29717197
17.

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend S, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB.

Diabetes. 2018 Apr 30. pii: db180158. doi: 10.2337/db18-0158. [Epub ahead of print]

PMID:
29712667
18.

Activation of TGR5 promotes mitochondrial biogenesis in human aortic endothelial cells.

Zhao LJ, Zhang SF.

Biochem Biophys Res Commun. 2018 Jun 12;500(4):952-957. doi: 10.1016/j.bbrc.2018.04.210. Epub 2018 May 2.

PMID:
29709472
19.

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.

20.

Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.

Agarwal S, Sasane S, Kumar J, Deshmukh P, Bhayani H, Giri P, Giri S, Soman S, Kulkarni N, Jain M.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1849-1852. doi: 10.1016/j.bmcl.2018.04.011. Epub 2018 Apr 5.

PMID:
29655980

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