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Evaluation of Biliary Calprotectin as a Biomarker in Primary Sclerosing Cholangitis.

Gauss A, Sauer P, Stiehl A, Rupp C, Krisam J, Leopold Y, Kloeters-Plachky P, Stremmel W, Gotthardt D.

Medicine (Baltimore). 2016 Apr;95(17):e3510. doi: 10.1097/MD.0000000000003510.


Editorial: further evidence for the role of serum alkaline phosphatase as a useful surrogate marker of prognosis in PSC - authors' reply.

Rupp C, Stiehl A, Trauner M, Gotthardt DN.

Aliment Pharmacol Ther. 2015 Jan;41(1):151-2. doi: 10.1111/apt.13020. No abstract available.


Reduction in alkaline phosphatase is associated with longer survival in primary sclerosing cholangitis, independent of dominant stenosis.

Rupp C, Rössler A, Halibasic E, Sauer P, Weiss KH, Friedrich K, Wannhoff A, Stiehl A, Stremmel W, Trauner M, Gotthardt DN.

Aliment Pharmacol Ther. 2014 Dec;40(11-12):1292-301. doi: 10.1111/apt.12979. Epub 2014 Oct 14.


Kinetics of primary bile acids in patients after proctocolectomy and ileal pouch-anal anastomosis.

Gotthardt DN, Sauer P, Schaible A, Stern J, Stiehl A, Beuers U.

Digestion. 2014;90(1):27-32. doi: 10.1159/000362403. Epub 2014 Aug 13.


Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis.

Gauss A, Ehehalt R, Lehmann WD, Erben G, Weiss KH, Schaefer Y, Kloeters-Plachky P, Stiehl A, Stremmel W, Sauer P, Gotthardt DN.

World J Gastroenterol. 2013 Sep 7;19(33):5454-63. doi: 10.3748/wjg.v19.i33.5454.


A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis.

Friedrich K, Rupp C, Hov JR, Steinebrunner N, Weiss KH, Stiehl A, Brune M, Schaefer PK, Schemmer P, Sauer P, Schirmacher P, Runz H, Karlsen TH, Stremmel W, Gotthardt DN.

PLoS One. 2013;8(3):e58734. doi: 10.1371/journal.pone.0058734. Epub 2013 Mar 7.


Oblique bile duct predisposes to the recurrence of bile duct stones.

Strnad P, von Figura G, Gruss R, Jareis KM, Stiehl A, Kulaksiz H.

PLoS One. 2013;8(1):e54601. doi: 10.1371/journal.pone.0054601. Epub 2013 Jan 24.


Non-IBD immunological diseases are a risk factor for reduced survival in PSC.

Rupp C, Mummelthei A, Sauer P, Weiss KH, Schirmacher P, Stiehl A, Stremmel W, Gotthardt DN.

Liver Int. 2013 Jan;33(1):86-93. doi: 10.1111/liv.12028. Epub 2012 Nov 14.


In PSC with colitis treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment.

Rudolph G, Gotthardt DN, Kloeters-Plachky P, Kulaksiz H, Schirmacher P, Stiehl A.

Dig Dis Sci. 2011 Dec;56(12):3624-30. doi: 10.1007/s10620-011-1763-2. Epub 2011 Jun 9.


Hepcidin is an antibacterial, stress-inducible peptide of the biliary system.

Strnad P, Schwarz P, Rasenack MC, Kucukoglu O, Habib RI, Heuberger D, Ehehalt R, Müller MW, Stiehl A, Adler G, Kulaksiz H.

PLoS One. 2011 Jan 24;6(1):e16454. doi: 10.1371/journal.pone.0016454.


A novel method of forceps biopsy improves the diagnosis of proximal biliary malignancies.

Kulaksiz H, Strnad P, Römpp A, von Figura G, Barth T, Esposito I, Schirmacher P, Henne-Bruns D, Adler G, Stiehl A.

Dig Dis Sci. 2011 Feb;56(2):596-601. doi: 10.1007/s10620-010-1535-4. Epub 2011 Jan 8.


Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH.

Nat Genet. 2011 Jan;43(1):17-9. doi: 10.1038/ng.728. Epub 2010 Dec 12.


Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH; IBSEN Study Group, Stokkers PC, Vermeire S, Mathew CG, Lie BA, Beuers U, Manns MP, Schreiber S, Schrumpf E, Häussinger D, Franke A, Karlsen TH.

PLoS One. 2010 Aug 25;5(8):e12403. doi: 10.1371/journal.pone.0012403.


Endoscopic retrograde cholangiopancreatography in diagnosis and treatment of primary sclerosing cholangitis.

Gotthardt D, Stiehl A.

Clin Liver Dis. 2010 May;14(2):349-58. doi: 10.1016/j.cld.2010.03.010. Review.


In PSC with dominant bile duct stenosis, IBD is associated with an increase of carcinomas and reduced survival.

Rudolph G, Gotthardt D, Kloeters-Plachky P, Rost D, Kulaksiz H, Stiehl A.

J Hepatol. 2010 Aug;53(2):313-7. doi: 10.1016/j.jhep.2010.02.030. Epub 2010 Apr 27.


Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment.

Gotthardt DN, Rudolph G, Klöters-Plachky P, Kulaksiz H, Stiehl A.

Gastrointest Endosc. 2010 Mar;71(3):527-34. doi: 10.1016/j.gie.2009.10.041.


Genome-wide association analysis in primary sclerosing cholangitis.

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P, Stiehl A, Vermeire S, Beuers U, Manns MP, Schrumpf E, Boberg KM, Schreiber S.

Gastroenterology. 2010 Mar;138(3):1102-11. doi: 10.1053/j.gastro.2009.11.046. Epub 2009 Nov 26.


Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis.

Rudolph G, Gotthardt D, Klöters-Plachky P, Kulaksiz H, Rost D, Stiehl A.

J Hepatol. 2009 Jul;51(1):149-55. doi: 10.1016/j.jhep.2009.01.023. Epub 2009 Mar 27.


A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults.

Gotthardt D, Runz H, Keitel V, Fischer C, Flechtenmacher C, Wirtenberger M, Weiss KH, Imparato S, Braun A, Hemminki K, Stremmel W, Rüschendorf F, Stiehl A, Kubitz R, Burwinkel B, Schirmacher P, Knisely AS, Zschocke J, Sauer P.

Hepatology. 2008 Oct;48(4):1157-66. doi: 10.1002/hep.22485.


Secondary sclerosing cholangitis after intensive care unit treatment: clues to the histopathological differential diagnosis.

Esposito I, Kubisova A, Stiehl A, Kulaksiz H, Schirmacher P.

Virchows Arch. 2008 Oct;453(4):339-45. doi: 10.1007/s00428-008-0654-1. Epub 2008 Sep 4.


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