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Items: 19

1.

Pregnane X Receptor Polymorphisms and Risk of Inflammatory Bowel Disease: A Meta-Analysis.

Guo X, Yan M.

Immunol Invest. 2017 Aug;46(6):566-576. doi: 10.1080/08820139.2017.1322101. Epub 2017 Jul 25.

PMID:
28742404
2.

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y.

Drug Des Devel Ther. 2015 Dec 7;9:6343-62. doi: 10.2147/DDDT.S79388. eCollection 2015.

3.

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.

Sehirli AO, Cetinel S, Ozkan N, Selman S, Tetik S, Yuksel M, Dulger FG.

J Physiol Pharmacol. 2015 Apr;66(2):203-14.

4.

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.

Dou W, Zhang J, Li H, Kortagere S, Sun K, Ding L, Ren G, Wang Z, Mani S.

J Nutr Biochem. 2014 Sep;25(9):923-33. doi: 10.1016/j.jnutbio.2014.04.006. Epub 2014 May 9.

5.

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.

Terc J, Hansen A, Alston L, Hirota SA.

Eur J Pharm Sci. 2014 May 13;55:12-9. doi: 10.1016/j.ejps.2014.01.007. Epub 2014 Jan 29.

PMID:
24486481
6.

Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium-induced murine colitis.

Kusunoki Y, Ikarashi N, Hayakawa Y, Ishii M, Kon R, Ochiai W, Machida Y, Sugiyama K.

Eur J Pharm Sci. 2014 Apr 11;54:17-27. doi: 10.1016/j.ejps.2013.12.019. Epub 2014 Jan 8.

PMID:
24413062
7.

Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.

Iwamoto J, Saito Y, Honda A, Miyazaki T, Ikegami T, Matsuzaki Y.

Inflamm Bowel Dis. 2013 May;19(6):1278-84. doi: 10.1097/MIB.0b013e318281f423.

PMID:
23574760
8.

Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.

Glas J, Seiderer J, Fischer D, Tengler B, Pfennig S, Wetzke M, Beigel F, Olszak T, Weidinger M, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S.

Inflamm Bowel Dis. 2011 Sep;17(9):1917-24. doi: 10.1002/ibd.21562. Epub 2010 Dec 3.

PMID:
21830270
9.

Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.

Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U.

World J Gastroenterol. 2011 Jan 14;17(2):197-206. doi: 10.3748/wjg.v17.i2.197.

10.

Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells.

Mencarelli A, Migliorati M, Barbanti M, Cipriani S, Palladino G, Distrutti E, Renga B, Fiorucci S.

Biochem Pharmacol. 2010 Dec 1;80(11):1700-7. doi: 10.1016/j.bcp.2010.08.022. Epub 2010 Sep 9.

PMID:
20816942
11.

Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.

Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ.

J Pharmacol Exp Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225. Epub 2010 Jul 13.

12.

Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice.

Jahnel J, Fickert P, Langner C, Högenauer C, Silbert D, Gumhold J, Fuchsbichler A, Trauner M.

Liver Int. 2009 Oct;29(9):1316-25. doi: 10.1111/j.1478-3231.2009.02044.x. Epub 2009 Jun 24.

PMID:
19558576
13.

Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

Lacher M, Kappler R, Schroepf S, Berkholz S, Ballauff A, Bufler P, Baurecht H, von Schweinitz D, Koletzko S.

J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):147-50. doi: 10.1097/MPG.0b013e31818de1a8.

PMID:
19516190
14.

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach.

Amre DK, Mack DR, Israel D, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Deslandres C, Levy E, Seidman EG.

Inflamm Bowel Dis. 2008 Sep;14(9):1214-8. doi: 10.1002/ibd.20461.

PMID:
18381611
15.

Role of the PXR gene locus in inflammatory bowel diseases.

Martínez A, Márquez A, Mendoza J, Taxonera C, Fernández-Arquero M, Díaz-Rubio M, de la Concha EG, Urcelay E.

Inflamm Bowel Dis. 2007 Dec;13(12):1484-7.

PMID:
17828778
16.

Coordinated defence and the liver.

Elias E, Mills CO.

Clin Med (Lond). 2007 Apr;7(2):180-4.

PMID:
17491508
17.

Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels.

Blokzijl H, Vander Borght S, Bok LI, Libbrecht L, Geuken M, van den Heuvel FA, Dijkstra G, Roskams TA, Moshage H, Jansen PL, Faber KN.

Inflamm Bowel Dis. 2007 Jun;13(6):710-20.

PMID:
17262809
18.

The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.

Dring MM, Goulding CA, Trimble VI, Keegan D, Ryan AW, Brophy KM, Smyth CM, Keeling PW, O'Donoghue D, O'Sullivan M, O'Morain C, Mahmud N, Wikström AC, Kelleher D, McManus R.

Gastroenterology. 2006 Feb;130(2):341-8; quiz 592.

PMID:
16472590
19.

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

Langmann T, Moehle C, Mauerer R, Scharl M, Liebisch G, Zahn A, Stremmel W, Schmitz G.

Gastroenterology. 2004 Jul;127(1):26-40.

PMID:
15236169

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