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Items: 1 to 20 of 38

1.

Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.

Pollheimer MJ, Racedo S, Mikels-Vigdal A, Marshall D, Bowlus C, Lackner C, Madl T, Karlsen TH, Hov JR, Lyman SK, Adamkewicz J, Smith V, Moreau E, Zollner G, Eide TJ, Stojakovic T, Scharnagl H, Gruber HJ, Stauber RE, Trauner M, Fickert P.

J Hepatol. 2018 Apr 28. pii: S0168-8278(18)32017-8. doi: 10.1016/j.jhep.2018.04.009. [Epub ahead of print]

PMID:
29709678
2.

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.

Tedesco D, Thapa M, Chin CY, Ge Y, Gong M, Li J, Gumber S, Speck P, Elrod EJ, Burd EM, Kitchens WH, Magliocca JF, Adams AB, Weiss DS, Mohamadzadeh M, Grakoui A.

Gastroenterology. 2018 Jun;154(8):2178-2193. doi: 10.1053/j.gastro.2018.02.019. Epub 2018 Feb 15.

PMID:
29454797
3.

Genetic determinants of cholangiopathies: Molecular and systems genetics.

Reichert MC, Hall RA, Krawczyk M, Lammert F.

Biochim Biophys Acta. 2018 Apr;1864(4 Pt B):1484-1490. doi: 10.1016/j.bbadis.2017.07.029. Epub 2017 Jul 27. Review.

PMID:
28757171
4.

ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.

Andress EJ, Nicolaou M, McGeoghan F, Linton KJ.

Cell Mol Life Sci. 2017 Jul;74(13):2513-2524. doi: 10.1007/s00018-017-2472-6. Epub 2017 Feb 20.

5.

Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging.

Müller A, Hochrath K, Stroeder J, Hittatiya K, Schneider G, Lammert F, Buecker A, Fries P.

Biomed Res Int. 2017;2017:8720367. doi: 10.1155/2017/8720367. Epub 2017 Jan 18.

6.

ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A.

O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF.

J Biol Chem. 2017 Mar 24;292(12):4833-4846. doi: 10.1074/jbc.M117.777409. Epub 2017 Feb 8.

7.

TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.

Weber SN, Bohner A, Dapito DH, Schwabe RF, Lammert F.

PLoS One. 2016 Jul 8;11(7):e0158819. doi: 10.1371/journal.pone.0158819. eCollection 2016.

8.

Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model.

Reiter FP, Wimmer R, Wottke L, Artmann R, Nagel JM, Carranza MO, Mayr D, Rust C, Fickert P, Trauner M, Gerbes AL, Hohenester S, Denk GU.

World J Hepatol. 2016 Mar 18;8(8):401-10. doi: 10.4254/wjh.v8.i8.401.

9.

Bile acid signaling and biliary functions.

Jones H, Alpini G, Francis H.

Acta Pharm Sin B. 2015 Mar;5(2):123-8. doi: 10.1016/j.apsb.2015.01.009. Epub 2015 Feb 19. Review.

10.

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.

Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M.

J Hepatol. 2016 Mar;64(3):674-81. doi: 10.1016/j.jhep.2015.10.024. Epub 2015 Oct 31.

11.

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice.

Zhou M, Learned RM, Rossi SJ, DePaoli AM, Tian H, Ling L.

Hepatology. 2016 Mar;63(3):914-29. doi: 10.1002/hep.28257. Epub 2015 Nov 30.

12.

ABCB4 mutations in adult patients with cholestatic liver disease: impact and phenotypic expression.

Degiorgio D, Crosignani A, Colombo C, Bordo D, Zuin M, Vassallo E, Syrén ML, Coviello DA, Battezzati PM.

J Gastroenterol. 2016 Mar;51(3):271-80. doi: 10.1007/s00535-015-1110-z. Epub 2015 Sep 1.

PMID:
26324191
13.

1,25-(OH)₂-vitamin D₃ prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model.

Reiter FP, Hohenester S, Nagel JM, Wimmer R, Artmann R, Wottke L, Makeschin MC, Mayr D, Rust C, Trauner M, Denk GU.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):227-33. doi: 10.1016/j.bbrc.2015.02.074. Epub 2015 Feb 21.

PMID:
25712522
14.

A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.

Ikenaga N, Liu SB, Sverdlov DY, Yoshida S, Nasser I, Ke Q, Kang PM, Popov Y.

Am J Pathol. 2015 Feb;185(2):325-34. doi: 10.1016/j.ajpath.2014.10.013. Epub 2014 Dec 2.

PMID:
25478810
15.

Vitamin D modulates biliary fibrosis in ABCB4-deficient mice.

Hochrath K, Stokes CS, Geisel J, Pollheimer MJ, Fickert P, Dooley S, Lammert F.

Hepatol Int. 2014 Jun 21;8(3):443-52. doi: 10.1007/s12072-014-9548-2. eCollection 2014 Jul.

16.

Cholestatic liver disease.

Jüngst C, Lammert F.

Dig Dis. 2013;31(1):152-4. doi: 10.1159/000347210. Epub 2013 Jun 17. Review.

PMID:
23797137
17.

Hepatobiliary anomalies associated with ABCB4/MDR3 deficiency in adults: a pictorial essay.

Benzimra J, Derhy S, Rosmorduc O, Menu Y, Poupon R, Arrivé L.

Insights Imaging. 2013 Jun;4(3):331-8. doi: 10.1007/s13244-013-0243-y. Epub 2013 Apr 17.

18.

The genetics of complex cholestatic disorders.

Hirschfield GM, Chapman RW, Karlsen TH, Lammert F, Lazaridis KN, Mason AL.

Gastroenterology. 2013 Jun;144(7):1357-74. doi: 10.1053/j.gastro.2013.03.053. Epub 2013 Apr 10. Review.

19.

Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model.

Mende S, Schulte S, Strack I, Hunt H, Odenthal M, Pryymachuck G, Quasdorff M, Demir M, Nierhoff D, Dienes HP, Goeser T, Steffen HM, Töx U.

Dig Dis Sci. 2013 May;58(5):1271-81. doi: 10.1007/s10620-012-2499-3. Epub 2012 Dec 18.

PMID:
23247798
20.

Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations.

Wendum D, Barbu V, Rosmorduc O, Arrivé L, Fléjou JF, Poupon R.

Virchows Arch. 2012 Mar;460(3):291-8. doi: 10.1007/s00428-012-1202-6. Epub 2012 Feb 14.

PMID:
22331132

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