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Items: 1 to 20 of 402

1.

Pancreatobiliary ductal dilatation: unique pathobiological processes and endoscopic revelations.

Abramyan O, LaRusso NF, Tabibian JH.

Gastroenterology. 2018 Oct 26. pii: S0016-5085(18)35198-9. doi: 10.1053/j.gastro.2018.10.041. [Epub ahead of print] No abstract available.

PMID:
30612998
2.

Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis.

Tietz-Bogert PS, Kim M, Cheung A, Tabibian JH, Heimbach JK, Rosen CB, Nandakumar M, Lazaridis KN, LaRusso NF, Sung J, O'Hara SP.

Int J Mol Sci. 2018 Oct 16;19(10). pii: E3188. doi: 10.3390/ijms19103188.

3.

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.

Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ.

J Hepatol. 2018 Sep;69(3):676-686. doi: 10.1016/j.jhep.2018.05.018. Epub 2018 May 24.

PMID:
29802947
4.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.

5.

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning.

Eaton JE, Vesterhus M, McCauley BM, Atkinson EJ, Schlicht EM, Juran BD, Gossard AA, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN.

Hepatology. 2018 May 9. doi: 10.1002/hep.30085. [Epub ahead of print]

PMID:
29742811
6.

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.

Mansini AP, Lorenzo Pisarello MJ, Thelen KM, Cruz-Reyes M, Peixoto E, Jin S, Howard BN, Trussoni CE, Gajdos GB, LaRusso NF, Perugorria MJ, Banales JM, Gradilone SA.

Hepatology. 2018 Aug;68(2):561-573. doi: 10.1002/hep.29832. Epub 2018 May 21.

PMID:
29406621
7.

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease.

Lorenzo Pisarello M, Masyuk TV, Gradilone SA, Masyuk AI, Ding JF, Lee PY, LaRusso NF.

Am J Pathol. 2018 Apr;188(4):981-994. doi: 10.1016/j.ajpath.2017.12.016. Epub 2018 Jan 31.

PMID:
29366679
8.

Cholangiocytes in health and disease: From basic science to novel treatments.

Banales JM, Marzioni M, LaRusso NF, Jansen P.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1217-1219. doi: 10.1016/j.bbadis.2018.01.014. Epub 2018 Jan 31. No abstract available.

9.

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history.

Murillo Perez CF, Goet JC, Lammers WJ, Gulamhusein A, van Buuren HR, Ponsioen CY, Carbone M, Mason A, Corpechot C, Invernizzi P, Mayo MJ, Battezzati PM, Floreani A, Pares A, Nevens F, Kowdley KV, Bruns T, Dalekos GN, Thorburn D, Hirschfield G, LaRusso NF, Lindor KD, Zachou K, Poupon R, Trivedi PJ, Verhelst X, Janssen HLA, Hansen BE; GLOBAL PBC Study Group.

Hepatology. 2018 May;67(5):1920-1930. doi: 10.1002/hep.29717. Epub 2018 Apr 6.

PMID:
29220537
10.

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis.

Masyuk TV, Masyuk AI, LaRusso NF.

Hepatology. 2018 Jun;67(6):2462-2464. doi: 10.1002/hep.29708. Epub 2018 Apr 19. No abstract available.

PMID:
29211938
11.

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target.

Masyuk AI, Masyuk TV, Lorenzo Pisarello MJ, Ding JF, Loarca L, Huang BQ, LaRusso NF.

Hepatology. 2018 Mar;67(3):1088-1108. doi: 10.1002/hep.29577. Epub 2018 Feb 1.

PMID:
29023824
12.

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation.

Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP, LaRusso NF, Bujanda L, Marin JJG, Banales JM.

Hepatology. 2018 Apr;67(4):1420-1440. doi: 10.1002/hep.29533. Epub 2018 Feb 21.

PMID:
28922472
13.

A 59-Year-Old Man With New Jaundice.

Mouchli MA, Kurtin PJ, LaRusso NF.

Gastroenterology. 2018 Jun;154(8):2035-2036. doi: 10.1053/j.gastro.2017.09.003. Epub 2017 Sep 9. No abstract available.

PMID:
28899720
14.

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis.

Loarca L, De Assuncao TM, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello MJL, Gores GJ, Huebert RC, LaRusso NF.

Lab Invest. 2017 Nov;97(11):1385-1396. doi: 10.1038/labinvest.2017.63. Epub 2017 Sep 11.

15.

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.

Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.

16.

Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?

O'Hara SP, Karlsen TH, LaRusso NF.

Gut. 2017 Nov;66(11):1873-1877. doi: 10.1136/gutjnl-2017-314249. Epub 2017 Jul 21. No abstract available.

17.

Pathobiology of biliary epithelia.

Cheung AC, Lorenzo Pisarello MJ, LaRusso NF.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1220-1231. doi: 10.1016/j.bbadis.2017.06.024. Epub 2017 Jul 15. Review.

18.

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Cheung AC, LaRusso NF, Gores GJ, Lazaridis KN.

Semin Liver Dis. 2017 May;37(2):159-174. doi: 10.1055/s-0037-1603324. Epub 2017 May 31. No abstract available.

19.

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.

Masyuk TV, Masyuk AI, Lorenzo Pisarello M, Howard BN, Huang BQ, Lee PY, Fung X, Sergienko E, Ardecky RJ, Chung TDY, Pinkerton AB, LaRusso NF.

Hepatology. 2017 Oct;66(4):1197-1218. doi: 10.1002/hep.29284. Epub 2017 Aug 26.

20.

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis.

Cheung AC, Juran BD, Moore RM, LaRusso NF, Lazaridis KN.

J Hepatol. 2017 Sep;67(3):651-652. doi: 10.1016/j.jhep.2017.02.036. Epub 2017 Apr 29. No abstract available.

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