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TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-IL-27 antibody for maximal protection and Treg upregulation.

Gaignage M, Marillier RG, Cochez PM, Dumoutier L, Uyttenhove C, Coutelier JP, Van Snick J.

Haematologica. 2018 Sep 13. pii: haematol.2018.195628. doi: 10.3324/haematol.2018.195628. [Epub ahead of print]


IL-27 amplifies cytokine responses to Gram-negative bacterial products and Salmonella typhimurium infection.

Petes C, Odoardi N, Plater SM, Martin NL, Gee K.

Sci Rep. 2018 Sep 12;8(1):13704. doi: 10.1038/s41598-018-32007-y.


Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients.

Tharwat E, Gad GFM, Nazmy MH, Mohamed HI, Hamza N, Wahid A, Ibrahim ARN.

Immunol Invest. 2018 Sep 11:1-13. doi: 10.1080/08820139.2018.1510958. [Epub ahead of print]


Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis.

Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaas9822. doi: 10.1126/sciimmunol.aas9822.


Natural Killer Cells: Development, Maturation, and Clinical Utilization.

Abel AM, Yang C, Thakar MS, Malarkannan S.

Front Immunol. 2018 Aug 13;9:1869. doi: 10.3389/fimmu.2018.01869. eCollection 2018. Review.


IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism.

Bruni D, Dignam A, Dunne S, Wall-Coughlan D, McCrudden A, O'Connell K, Lyons C, McGuigan C, Tubridy N, Butler MP.

J Immunol. 2018 Oct 1;201(7):2070-2081. doi: 10.4049/jimmunol.1701373. Epub 2018 Aug 24.


Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production.

Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, de Paulis A, Marone G, El Shikh MEM, Humby F, Pitzalis C.

Ann Rheum Dis. 2018 Aug 20. pii: annrheumdis-2018-213418. doi: 10.1136/annrheumdis-2018-213418. [Epub ahead of print]


Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis.

Meka RR, Venkatesha SH, Moudgil KD.

J Control Release. 2018 Sep 28;286:279-288. doi: 10.1016/j.jconrel.2018.08.007. Epub 2018 Aug 4.


Interleukin-27 is a potential marker for the onset of post-transplant malignancies.

Pontrelli P, Rascio F, Zaza G, Accetturo M, Simone S, Infante B, Furian L, Castellano G, Ditonno P, Battaglia M, Cormio L, Carrieri G, Lupo A, Rigotti P, Gesualdo L, Stallone G, Grandaliano G.

Nephrol Dial Transplant. 2018 Jul 27. doi: 10.1093/ndt/gfy206. [Epub ahead of print]


IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.

Wehrens EJ, Wong KA, Gupta A, Khan A, Benedict CA, Zuniga EI.

PLoS One. 2018 Jul 25;13(7):e0201249. doi: 10.1371/journal.pone.0201249. eCollection 2018.


The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.

Rolvering C, Zimmer AD, Ginolhac A, Margue C, Kirchmeyer M, Servais F, Hermanns HM, Hergovits S, Nazarov PV, Nicot N, Kreis S, Haan S, Behrmann I, Haan C.

J Leukoc Biol. 2018 Jul 24. doi: 10.1002/JLB.MA1217-495R. [Epub ahead of print]


Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells.

Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T.

Inflammation. 2018 Jul 24. doi: 10.1007/s10753-018-0854-z. [Epub ahead of print]


Interleukin-27 controls basal pain threshold in physiological and pathological conditions.

Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka T.

Sci Rep. 2018 Jul 23;8(1):11022. doi: 10.1038/s41598-018-29398-3.


Dyslipidemia promotes germinal center reactions via IL-27.

Ryu H, Chung Y.

BMB Rep. 2018 Aug;51(8):371-372.


δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients.

Qureshi AA, Khan DA, Mushtaq S, Ye SQ, Xiong M, Qureshi N.

Lipids Health Dis. 2018 Jul 21;17(1):167. doi: 10.1186/s12944-018-0804-7.


IL-27 regulates HIF-1α-mediated VEGFA response in macrophages of diabetic retinopathy patients and healthy individuals.

Zhang Q, Cunha APD, Li S, Hao Q, Kainz V, Huang Q, Wu HY.

Cytokine. 2018 Jul 12. pii: S1043-4666(18)30298-9. doi: 10.1016/j.cyto.2018.07.011. [Epub ahead of print]


Inflammation and immune resolution.

Taams LS.

Clin Exp Immunol. 2018 Jul;193(1):1-2. doi: 10.1111/cei.13155.


Soluble interleukin-27 receptor alpha is a valuable prognostic biomarker for acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

Liu S, Han J, Gong H, Li Y, Bao X, Qi J, Liu H, Chen J, Wu X, Xu Y, Ma S, Wu D.

Sci Rep. 2018 Jul 9;8(1):10328. doi: 10.1038/s41598-018-28614-4.

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