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The influences of cholecystectomy on the circadian rhythms of bile acids as well as the enterohepatic transporters and enzymes systems in mice.

Zhang F, Duan Y, Xi L, Wei M, Shi A, Zhou Y, Wei Y, Wu X.

Chronobiol Int. 2018 May;35(5):673-690. doi: 10.1080/07420528.2018.1426596. Epub 2018 Jan 30.


Epigallocatechin gallate induces a hepatospecific decrease in the CYP3A expression level by altering intestinal flora.

Ikarashi N, Ogawa S, Hirobe R, Kon R, Kusunoki Y, Yamashita M, Mizukami N, Kaneko M, Wakui N, Machida Y, Sugiyama K.

Eur J Pharm Sci. 2017 Mar 30;100:211-218. doi: 10.1016/j.ejps.2017.01.022. Epub 2017 Jan 21.


Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.

Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.

Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18.


An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay.

Bansal S, Chai SF, Lau AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 15;1023-1024:1-8. doi: 10.1016/j.jchromb.2016.04.039. Epub 2016 Apr 27.


Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.

Zeng H, Li D, Qin X, Chen P, Tan H, Zeng X, Li X, Fan X, Jiang Y, Zhou Y, Chen Y, Wang Y, Huang M, Bi H.

Drug Metab Dispos. 2016 Mar;44(3):337-42. doi: 10.1124/dmd.115.066969. Epub 2015 Dec 10.


Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates.

Erratico CA, Deo AK, Bandiera SM.

Adv Exp Med Biol. 2015;851:131-49. doi: 10.1007/978-3-319-16009-2_5. Review.


Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes.

Avior Y, Levy G, Zimerman M, Kitsberg D, Schwartz R, Sadeh R, Moussaieff A, Cohen M, Itskovitz-Eldor J, Nahmias Y.

Hepatology. 2015 Jul;62(1):265-78. doi: 10.1002/hep.27803. Epub 2015 Apr 22.


Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor.

Zhang X, Ma Z, Liang Q, Tang X, Hu D, Liu C, Tan H, Xiao C, Zhang B, Wang Y, Gao Y.

J Ethnopharmacol. 2015 Apr 22;164:357-67. doi: 10.1016/j.jep.2015.01.047. Epub 2015 Feb 7.


Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.

Je YT, Sim WC, Kim DG, Jung BH, Shin HS, Lee BH.

Arch Toxicol. 2015 Apr;89(4):579-89. doi: 10.1007/s00204-014-1268-9. Epub 2014 May 23.


Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice.

Hrycay E, Forrest D, Liu L, Wang R, Tai J, Deo A, Ling V, Bandiera S.

Mol Cell Biochem. 2014 Apr;389(1-2):119-32. doi: 10.1007/s11010-013-1933-y. Epub 2014 Jan 8.


Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.

Cheng J, Fang ZZ, Kim JH, Krausz KW, Tanaka N, Chiang JY, Gonzalez FJ.

J Lipid Res. 2014 Mar;55(3):455-65. doi: 10.1194/jlr.M044420. Epub 2013 Dec 16.


Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice.

Ishii M, Toda T, Ikarashi N, Kusunoki Y, Kon R, Ochiai W, Machida Y, Sugiyama K.

Biol Pharm Bull. 2014;37(2):298-305. Epub 2013 Nov 23.


Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme.

Tajima M, Ikarashi N, Igeta S, Toda T, Ishii M, Tanaka Y, Machida Y, Ochiai W, Yamada H, Sugiyama K.

Biol Pharm Bull. 2013;36(4):624-34. Epub 2013 Feb 1.


Consumption of a high-fat diet during pregnancy changes the expression of cytochrome P450 in the livers of infant male mice.

Tajima M, Ikarashi N, Okaniwa T, Imahori Y, Saruta K, Toda T, Ishii M, Tanaka Y, Machida Y, Ochiai W, Yamada H, Sugiyama K.

Biol Pharm Bull. 2013;36(4):649-57. Epub 2013 Jan 28.


Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line.

Wassmur B, Gräns J, Norström E, Wallin M, Celander MC.

Toxicol In Vitro. 2013 Feb;27(1):111-20. doi: 10.1016/j.tiv.2012.10.002. Epub 2012 Oct 12.


Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.

Wang YG, Zhou JM, Ma ZC, Li H, Liang QD, Tan HL, Xiao CR, Zhang BL, Gao Y.

Chem Biol Interact. 2012 Oct 25;200(1):11-20. doi: 10.1016/j.cbi.2012.08.023. Epub 2012 Sep 13.


An antioxidant Trolox restores decreased oral absorption of cyclosporine A after liver ischemia-reperfusion through distinct mechanisms between CYP3A and P-glycoprotein in the small intestine.

Ikemura K, Inoue K, Mizutani H, Oka H, Iwamoto T, Okuda M.

Eur J Pharmacol. 2012 Sep 5;690(1-3):192-201. doi: 10.1016/j.ejphar.2012.06.031. Epub 2012 Jun 30.


[Effects of intestinal flora on the expression of cytochrome P450 3A in the liver].

Ishii M, Toda T, Ikarashi N, Ochiai W, Sugiyama K.

Yakugaku Zasshi. 2012;132(3):301-10. Review. Japanese.


A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.

Bailey I, Gibson GG, Plant K, Graham M, Plant N.

PLoS One. 2011 Feb 2;6(2):e16703. doi: 10.1371/journal.pone.0016703.


The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.

Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM.

Toxicol In Vitro. 2011 Feb;25(1):80-90. doi: 10.1016/j.tiv.2010.09.011. Epub 2010 Oct 1.


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