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Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK.

Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4.


The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical Mice.

Nelson RW, Rajpal MN, Jenkins MK.

J Immunol. 2015 Sep 1;195(5):2115-21. doi: 10.4049/jimmunol.1500405. Epub 2015 Jul 15.


Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

Tubo NJ, Pagán AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK.

Cell. 2013 May 9;153(4):785-96. doi: 10.1016/j.cell.2013.04.007.


CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.

Nelson RW, McLachlan JB, Kurtz JR, Jenkins MK.

J Immunol. 2013 Mar 15;190(6):2828-34. doi: 10.4049/jimmunol.1202183. Epub 2013 Feb 4.

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